ENSDARG00000100741


Danio rerio

Features
Gene ID: ENSDARG00000100741
  
Biological name :cdc20
  
Synonyms : cdc20 / cell division cycle 20 homolog
  
Possible biological names infered from orthology : Cell division cycle / cell division cycle 20 / Q12834 / Q9JJ66
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 19217586
Gene end: 19234469
  
Corresponding Affymetrix probe sets: Dr.26337.1.A1_at (Zebrafish Array)   NM_213080_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000133875
Ensembl peptide - ENSDARP00000143343
Ensembl peptide - ENSDARP00000140575
NCBI entrez gene - 406353     See in Manteia.
RefSeq - NM_213080
RefSeq - XM_009298475
RefSeq Peptide - NP_998245
swissprot - A0A0R4IU39
swissprot - A0A0R4IFE1
ZFIN ID - ZDB-GENE-040426-2044
Ensembl - ENSDARG00000100741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC20ENSGALG00000009971Gallus gallus
 CDC20ENSG00000117399Homo sapiens
 Cdc20ENSMUSG00000006398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fzr1b / fizzy/cell division cycle 20 related 1bENSDARG0000002281034
fzr1a / fizzy/cell division cycle 20 related 1a / FZR1* / Q9R1K5* / Q9UM11* / Fizzy-related protein homolog * / fizzy and cell division cycle 20 related 1*ENSDARG0000001525434


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family
 IPR033187  Cell division cycle protein 20 homologue


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite morphology , abnormal
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 ZFA:0001094 whole organism whole organism necrotic , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism cell low brightness , abnormal
whole organism cell spherical , abnormal
whole organism apoptotic process increased occurrence , abnormal
Show

 ZFA:0009000 cell cell binucleate , abnormal
cell mitotic prophase arrested , abnormal
cell mitotic metaphase arrested , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex
 ENSDARG00000058471 plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSDARG00000074927 bub1bb / BUB1 mitotic checkpoint serine/threonine kinase Bb / BUB1B* / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / reaction / complex
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction / complex
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex
 ENSDARG00000075883 bub3 / BUB3 mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / complex / reaction
 ENSDARG00000005619 nek2 / NIMA-related kinase 2 / O35942* / P51955* / Serine/threonine-protein kinase Nek2 *  / reaction / complex
 ENSDARG00000089861 usp44 / ubiquitin specific peptidase 44 / Q9H0E7*  / complex






 

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