ENSDARG00000089861


Danio rerio

Features
Gene ID: ENSDARG00000089861
  
Biological name :usp44
  
Synonyms : ubiquitin specific peptidase 44 / usp44
  
Possible biological names infered from orthology : Q8C2S0 / Q9H0E7
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 26021749
Gene end: 26035770
  
Corresponding Affymetrix probe sets: Dr.2726.1.S1_at (Zebrafish Array)   NM_200257_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000104741
Ensembl peptide - ENSDARP00000147626
NCBI entrez gene - 393227     See in Manteia.
RefSeq - NM_200257
RefSeq Peptide - NP_956551
swissprot - F2Z4V2
ZFIN ID - ZDB-GENE-040426-774
Ensembl - ENSDARG00000089861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP44ENSGALG00000011400Gallus gallus
 USP44ENSG00000136014Homo sapiens
 Usp44ENSMUSG00000020020Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp49 / ubiquitin specific peptidase 49 / Q6P9L4* / Q70CQ1*ENSDARG0000000022955
usp3 / ubiquitin specific peptidase 3 / Q91W36* / Q9Y6I4*ENSDARG0000004564125
usp22 / A6H8I0 / ubiquitin specific peptidase 22 / USP51* / Q70EK9* / Q8CEG8* / Q9UPT9* / B1AY15* / Q5DU02* / A6NNY8* / USP27X* / ubiquitin specific protease 51* / ubiquitin specific peptid...ENSDARG0000004040721
usp42 / ubiquitin specific peptidase 42 / B2RQC2* / Q9H9J4*ENSDARG0000007730017
usp36 / ubiquitin specific peptidase 36 / B1AQJ2* / Q9P275*ENSDARG0000003232716


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head immature , abnormal
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 ZFA:0001115 trunk trunk immature , abnormal
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 ZFA:0001117 post-vent region post-vent region necrotic , abnormal
post-vent region curled , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage shape , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / complex






 

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