ENSMUSG00000020020


Mus musculus

Features
Gene ID: ENSMUSG00000020020
  
Biological name :Usp44
  
Synonyms : Q8C2S0 / ubiquitin specific peptidase 44 / Usp44
  
Possible biological names infered from orthology : Q9H0E7
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C2
Gene start: 93831555
Gene end: 93858088
  
Corresponding Affymetrix probe sets: 10365833 (MoGene1.0st)   1456690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092975
Ensembl peptide - ENSMUSP00000149020
NCBI entrez gene - 327799     See in Manteia.
MGI - MGI:3045318
RefSeq - XM_011243490
RefSeq - NM_001206851
RefSeq - NM_183199
RefSeq - XM_011243486
RefSeq - XM_011243487
RefSeq - XM_011243488
RefSeq - XM_011243489
RefSeq - XM_011243479
RefSeq - XM_011243480
RefSeq - XM_011243481
RefSeq - XM_011243482
RefSeq - XM_011243483
RefSeq - XM_011243484
RefSeq - XM_011243485
RefSeq Peptide - NP_001193780
RefSeq Peptide - NP_899022
swissprot - Q8C2S0
swissprot - A0A0A0MQB2
Ensembl - ENSMUSG00000020020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp44ENSDARG00000089861Danio rerio
 USP44ENSGALG00000011400Gallus gallus
 USP44ENSG00000136014Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp49 / Q6P9L4 / ubiquitin specific peptidase 49 / Q70CQ1*ENSMUSG0000009011544
Usp3 / Q91W36 / ubiquitin specific peptidase 3 / Q9Y6I4*ENSMUSG0000003237619
Usp51 / B1AY15 / ubiquitin specific protease 51 / Q70EK9* / ubiquitin specific peptidase 51*ENSMUSG0000006721515
Usp22 / Q5DU02 / ubiquitin specific peptidase 22 / Q9UPT9*ENSMUSG0000004250615
Q8CEG8 / Usp27x / ubiquitin specific peptidase 27, X chromosome / A6NNY8* / ubiquitin specific peptidase 27, X-linked*ENSMUSG0000004626912
Usp36 / B1AQJ2 / ubiquitin specific peptidase 36 / Q9P275*ENSMUSG0000003390912
Usp42 / B2RQC2 / ubiquitin specific peptidase 42 / Q9H9J4*ENSMUSG0000005130610
Usp17le / ubiquitin specific peptidase 17-like E / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG000000430738
E9Q9U0 / Usp17lb / ubiquitin specific peptidase 17-like B / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG000000623698
Q61068 / Usp17la / ubiquitin specific peptidase 17-like A / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG000000545688
G5E8G2 / Usp17ld / ubiquitin specific peptidase 17-like D / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG000000573217
Usp17lc / ubiquitin specific peptidase 17-like C / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG000000589767


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint IDA
 biological_processGO:1904667 negative regulation of ubiquitin protein ligase activity ISO
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / complex






 

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