ENSMUSG00000032376


Mus musculus

Features
Gene ID: ENSMUSG00000032376
  
Biological name :Usp3
  
Synonyms : Q91W36 / ubiquitin specific peptidase 3 / Usp3
  
Possible biological names infered from orthology : Q9Y6I4
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 66514637
Gene end: 66593142
  
Corresponding Affymetrix probe sets: 10594613 (MoGene1.0st)   1425022_at (Mouse Genome 430 2.0 Array)   1425023_at (Mouse Genome 430 2.0 Array)   1435531_at (Mouse Genome 430 2.0 Array)   1441056_at (Mouse Genome 430 2.0 Array)   1444635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134472
Ensembl peptide - ENSMUSP00000096213
Ensembl peptide - ENSMUSP00000115620
Ensembl peptide - ENSMUSP00000122199
NCBI entrez gene - 235441     See in Manteia.
MGI - MGI:2152450
RefSeq - XM_017313341
RefSeq - NM_001302116
RefSeq - NM_001302122
RefSeq - NM_144937
RefSeq - XM_006511110
RefSeq - XM_011242729
RefSeq - XM_017313339
RefSeq - XM_017313340
RefSeq Peptide - NP_659186
RefSeq Peptide - NP_001289045
RefSeq Peptide - NP_001289051
swissprot - D6RG67
swissprot - Q91W36
swissprot - E9Q8W9
swissprot - G3UZF0
Ensembl - ENSMUSG00000032376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp3ENSDARG00000045641Danio rerio
 USP3ENSGALG00000003427Gallus gallus
 USP3ENSG00000140455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp49 / Q6P9L4 / ubiquitin specific peptidase 49 / Q70CQ1*ENSMUSG0000009011534
Usp22 / Q5DU02 / ubiquitin specific peptidase 22 / Q9UPT9*ENSMUSG0000004250626
Usp51 / B1AY15 / ubiquitin specific protease 51 / Q70EK9* / ubiquitin specific peptidase 51*ENSMUSG0000006721526
Q8CEG8 / Usp27x / ubiquitin specific peptidase 27, X chromosome / A6NNY8* / ubiquitin specific peptidase 27, X-linked*ENSMUSG0000004626923
Usp36 / B1AQJ2 / ubiquitin specific peptidase 36 / Q9P275*ENSMUSG0000003390922
Usp42 / B2RQC2 / ubiquitin specific peptidase 42 / Q9H9J4*ENSMUSG0000005130622
Usp17le / ubiquitin specific peptidase 17-like E / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000004307320
Usp17lc / ubiquitin specific peptidase 17-like C / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000005897619
Usp44 / Q8C2S0 / ubiquitin specific peptidase 44 / Q9H0E7*ENSMUSG0000002002019
G5E8G2 / Usp17ld / ubiquitin specific peptidase 17-like D / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005732119
Q61068 / Usp17la / ubiquitin specific peptidase 17-like A / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005456819
E9Q9U0 / Usp17lb / ubiquitin specific peptidase 17-like B / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000006236918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016578 histone deubiquitination IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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