ENSG00000140455


Homo sapiens

Features
Gene ID: ENSG00000140455
  
Biological name :USP3
  
Synonyms : Q9Y6I4 / ubiquitin specific peptidase 3 / USP3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.31
Gene start: 63504511
Gene end: 63594640
  
Corresponding Affymetrix probe sets: 221654_s_at (Human Genome U133 Plus 2.0 Array)   226652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454197
Ensembl peptide - ENSP00000453767
Ensembl peptide - ENSP00000454043
Ensembl peptide - ENSP00000268049
Ensembl peptide - ENSP00000369681
Ensembl peptide - ENSP00000445793
Ensembl peptide - ENSP00000445828
Ensembl peptide - ENSP00000452929
Ensembl peptide - ENSP00000452947
Ensembl peptide - ENSP00000453093
Ensembl peptide - ENSP00000453138
Ensembl peptide - ENSP00000453194
Ensembl peptide - ENSP00000453228
Ensembl peptide - ENSP00000453489
Ensembl peptide - ENSP00000453619
Ensembl peptide - ENSP00000453688
NCBI entrez gene - 9960     See in Manteia.
OMIM - 604728
RefSeq - XM_017022768
RefSeq - NM_001256702
RefSeq - NM_006537
RefSeq - XM_017022763
RefSeq - XM_017022764
RefSeq - XM_017022765
RefSeq - XM_017022766
RefSeq - XM_017022767
RefSeq Peptide - NP_001243631
RefSeq Peptide - NP_006528
swissprot - H0YNX9
swissprot - Q9Y6I4
swissprot - H0YKU8
swissprot - Q6JHV3
swissprot - H0YL81
swissprot - H0YLB7
swissprot - H0YLG0
swissprot - H0YLJ0
swissprot - H0YM72
swissprot - H0YMI4
swissprot - H0YMW1
swissprot - H0YMP6
swissprot - H0YNK1
Ensembl - ENSG00000140455
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp3ENSDARG00000045641Danio rerio
 USP3ENSGALG00000003427Gallus gallus
 Usp3ENSMUSG00000032376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP44 / Q9H0E7 / ubiquitin specific peptidase 44ENSG0000013601435
USP49 / Q70CQ1 / ubiquitin specific peptidase 49ENSG0000016466334
USP51 / Q70EK9 / ubiquitin specific peptidase 51ENSG0000024774627
USP22 / Q9UPT9 / ubiquitin specific peptidase 22ENSG0000012442226
USP42 / Q9H9J4 / ubiquitin specific peptidase 42ENSG0000010634623
A6NNY8 / USP27X / ubiquitin specific peptidase 27, X-linkedENSG0000027382023
USP36 / Q9P275 / ubiquitin specific peptidase 36ENSG0000005548322
C9JJH3 / USP17L10 / ubiquitin specific peptidase 17-like family member 10ENSG0000023139620
C9JVI0 / USP17L11 / ubiquitin specific peptidase 17-like family member 11ENSG0000023313620
Q0WX57 / USP17L24 / ubiquitin specific peptidase 17-like family member 24ENSG0000023226420
Q6R6M4 / USP17L2 / ubiquitin specific peptidase 17-like family member 2ENSG0000022344320
C9JLJ4 / USP17L13 / ubiquitin specific peptidase 17-like family member 13ENSG0000023239920
A8MUK1 / USP17L5 / ubiquitin specific peptidase 17-like family member 5ENSG0000022714020
C9J2P7 / USP17L15 / ubiquitin specific peptidase 17-like family member 15ENSG0000022356920
Q0WX57 / USP17L27 / ubiquitin specific peptidase 17-like family member 27ENSG0000023578020
Q0WX57 / USP17L25 / ubiquitin specific peptidase 17-like family member 25ENSG0000023043020
D6RJB6 / USP17L20 / ubiquitin specific peptidase 17-like family member 20ENSG0000025074520
D6R9N7 / USP17L18 / ubiquitin specific peptidase 17-like family member 18ENSG0000025084420
D6R901 / USP17L21 / ubiquitin specific peptidase 17-like family member 21ENSG0000024981120
Q0WX57 / USP17L30 / ubiquitin specific peptidase 17-like family member 30ENSG0000022885620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016578 histone deubiquitination IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0090543 Flemming body IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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