ENSG00000164663


Homo sapiens

Features
Gene ID: ENSG00000164663
  
Biological name :USP49
  
Synonyms : Q70CQ1 / ubiquitin specific peptidase 49 / USP49
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.1
Gene start: 41789896
Gene end: 41895361
  
Corresponding Affymetrix probe sets: 1564029_at (Human Genome U133 Plus 2.0 Array)   220667_at (Human Genome U133 Plus 2.0 Array)   222964_at (Human Genome U133 Plus 2.0 Array)   229351_at (Human Genome U133 Plus 2.0 Array)   242120_at (Human Genome U133 Plus 2.0 Array)   243392_at (Human Genome U133 Plus 2.0 Array)   244133_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411603
Ensembl peptide - ENSP00000362097
Ensembl peptide - ENSP00000362101
Ensembl peptide - ENSP00000377797
Ensembl peptide - ENSP00000389842
NCBI entrez gene - 25862     See in Manteia.
RefSeq - NM_018561
RefSeq - NM_001286554
RefSeq Peptide - NP_001273483
RefSeq Peptide - NP_061031
swissprot - Q70CQ1
swissprot - A6PVU3
swissprot - H7BZI7
swissprot - Q5T3E1
Ensembl - ENSG00000164663
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp49ENSDARG00000000229Danio rerio
 ENSGALG00000044132Gallus gallus
 ENSGALG00000003461Gallus gallus
 Usp49ENSMUSG00000090115Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP44 / Q9H0E7 / ubiquitin specific peptidase 44ENSG0000013601461
USP3 / Q9Y6I4 / ubiquitin specific peptidase 3ENSG0000014045525
USP51 / Q70EK9 / ubiquitin specific peptidase 51ENSG0000024774621
USP22 / Q9UPT9 / ubiquitin specific peptidase 22ENSG0000012442221
A6NNY8 / USP27X / ubiquitin specific peptidase 27, X-linkedENSG0000027382019
USP36 / Q9P275 / ubiquitin specific peptidase 36ENSG0000005548317
USP42 / Q9H9J4 / ubiquitin specific peptidase 42ENSG0000010634616
C9JJH3 / USP17L10 / ubiquitin specific peptidase 17-like family member 10ENSG0000023139615
D6R901 / USP17L21 / ubiquitin specific peptidase 17-like family member 21ENSG0000024981115
A8MUK1 / USP17L5 / ubiquitin specific peptidase 17-like family member 5ENSG0000022714015
Q0WX57 / USP17L25 / ubiquitin specific peptidase 17-like family member 25ENSG0000023043015
Q6R6M4 / USP17L2 / ubiquitin specific peptidase 17-like family member 2ENSG0000022344315
Q0WX57 / USP17L26 / ubiquitin specific peptidase 17-like family member 26ENSG0000022957915
D6RA61 / USP17L22 / ubiquitin specific peptidase 17-like family member 22ENSG0000024893315
Q0WX57 / USP17L29 / ubiquitin specific peptidase 17-like family member 29ENSG0000023163715
D6RCP7 / USP17L19 / ubiquitin specific peptidase 17-like family member 19ENSG0000024892015
C9JLJ4 / USP17L13 / ubiquitin specific peptidase 17-like family member 13ENSG0000023239915
Q0WX57 / USP17L27 / ubiquitin specific peptidase 17-like family member 27ENSG0000023578015
D6RJB6 / USP17L20 / ubiquitin specific peptidase 17-like family member 20ENSG0000025074515
D6R9N7 / USP17L18 / ubiquitin specific peptidase 17-like family member 18ENSG0000025084415


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0035616 histone H2B conserved C-terminal lysine deubiquitination IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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