ENSG00000223443


Homo sapiens

Features
Gene ID: ENSG00000223443
  
Biological name :USP17L2
  
Synonyms : Q6R6M4 / ubiquitin specific peptidase 17-like family member 2 / USP17L2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 12137168
Gene end: 12139077
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000333329
NCBI entrez gene - 377630     See in Manteia.
OMIM - 610186
RefSeq - NM_201402
RefSeq Peptide - NP_958804
swissprot - Q6R6M4
Ensembl - ENSG00000223443
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E9Q9U0ENSMUSG00000062369Mus musculus
 G5E8G2ENSMUSG00000057321Mus musculus
 Q61068ENSMUSG00000054568Mus musculus
 Usp17lcENSMUSG00000058976Mus musculus
 Usp17leENSMUSG00000043073Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A6NCW0 / USP17L3 / ubiquitin specific peptidase 17-like family member 3ENSG0000022532797
Q7RTZ2 / USP17L1 / ubiquitin specific peptidase 17-like family member 1ENSG0000023054996
P0C7I0 / USP17L8 / ubiquitin specific peptidase 17-like family member 8ENSG0000023703896
A6NCW7 / USP17L4 / ubiquitin specific peptidase 17-like family member 4ENSG0000023612596
C9JVI0 / USP17L11 / ubiquitin specific peptidase 17-like family member 11ENSG0000023313695
Q0WX57 / USP17L24 / ubiquitin specific peptidase 17-like family member 24ENSG0000023226495
Q0WX57 / USP17L30 / ubiquitin specific peptidase 17-like family member 30ENSG0000022885695
Q0WX57 / USP17L25 / ubiquitin specific peptidase 17-like family member 25ENSG0000023043095
Q0WX57 / USP17L27 / ubiquitin specific peptidase 17-like family member 27ENSG0000023578095
D6R9N7 / USP17L18 / ubiquitin specific peptidase 17-like family member 18ENSG0000025084495
D6RJB6 / USP17L20 / ubiquitin specific peptidase 17-like family member 20ENSG0000025074595
A8MUK1 / USP17L5 / ubiquitin specific peptidase 17-like family member 5ENSG0000022714095
Q0WX57 / USP17L26 / ubiquitin specific peptidase 17-like family member 26ENSG0000022957995
D6RA61 / USP17L22 / ubiquitin specific peptidase 17-like family member 22ENSG0000024893395
D6RCP7 / USP17L19 / ubiquitin specific peptidase 17-like family member 19ENSG0000024892095
Q0WX57 / USP17L29 / ubiquitin specific peptidase 17-like family member 29ENSG0000023163795
Q0WX57 / USP17L28 / ubiquitin specific peptidase 17-like family member 28ENSG0000023105195
D6RBQ6 / USP17L17 / ubiquitin specific peptidase 17-like family member 17ENSG0000024910495
C9J2P7 / USP17L15 / ubiquitin specific peptidase 17-like family member 15ENSG0000022356995
D6R901 / USP17L21 / ubiquitin specific peptidase 17-like family member 21ENSG0000024981194


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0010955 negative regulation of protein processing IMP
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0031064 negative regulation of histone deacetylation IMP
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0050691 regulation of defense response to virus by host IMP
 biological_processGO:0070536 protein K63-linked deubiquitination IMP
 biological_processGO:0071108 protein K48-linked deubiquitination IMP
 biological_processGO:0071586 CAAX-box protein processing IMP
 biological_processGO:0090315 negative regulation of protein targeting to membrane IMP
 biological_processGO:1900027 regulation of ruffle assembly IMP
 biological_processGO:1900245 positive regulation of MDA-5 signaling pathway IMP
 biological_processGO:1900246 positive regulation of RIG-I signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex
 ENSG00000111707 SUDS3 / Q9H7L9 / SDS3 homolog, SIN3A corepressor complex component  / complex
 ENSG00000173653 RCE1 / Q9Y256 / Ras converting CAAX endopeptidase 1  / complex






 

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