ENSMUSG00000058976


Mus musculus

Features
Gene ID: ENSMUSG00000058976
  
Biological name :Usp17lc
  
Synonyms : ubiquitin specific peptidase 17-like C / Usp17lc
  
Possible biological names infered from orthology : A6NCW0 / A6NCW7 / A8MUK1 / C9J2P7 / C9JJH3 / C9JLJ4 / C9JPN9 / C9JVI0 / D6R901 / D6R9N7 / D6RA61 / D6RBM5 / D6RBQ6 / D6RCP7 / D6RJB6 / P0C7H9 / P0C7I0 / Q0WX57 / Q6R6M4 / Q7RTZ2 / ubiquitin specific peptidase 17-like family member 1 / ubiquitin specific peptidase 17-like family member 10 / ubiquitin specific peptidase 17-like family member 11 / ubiquitin specific peptidase 17-like family member 12 / ubiquitin specific peptidase 17-like family member 13 / ubiquitin specific peptidase 17-like family member 15 / ubiquitin specific peptidase 17-like family member 17 / ubiquitin specific peptidase 17-like family member 18 / ubiquitin specific peptidase 17-like family member 19 / ubiquitin specific peptidase 17-like family member 2 / ubiquitin specific peptidase 17-like family member 20 / ubiquitin specific peptidase 17-like family member 21 / ubiquitin specific peptidase 17-like family member 22 / ubiquitin specific peptidase 17-like family member 23 / ubiquitin specific peptidase 17-like family member 24 / ubiquitin specific peptidase 17-like family member 25 / ubiquitin specific peptidase 17-like family member 26 / ubiquitin specific peptidase 17-like family member 27 / ubiquitin specific peptidase 17-like family member 28 / ubiquitin specific peptidase 17-like family member 29 / ubiquitin specific peptidase 17-like family member 3 / ubiquitin specific peptidase 17-like family member 30 / ubiquitin specific peptidase 17-like family member 4 / ubiquitin specific peptidase 17-like family member 5 / ubiquitin specific peptidase 17-like family member 7 / ubiquitin specific peptidase 17-like family member 8 / USP17L1 / USP17L10 / USP17L11 / USP17L12 / USP17L13 / USP17L15 / USP17L17 / USP17L18 / USP17L19 / USP17L2 / USP17L20 / USP17L21 / USP17L22 / USP17L23 / USP17L24 / USP17L25 / USP17L26 / USP17L27 / USP17L28 / USP17L29 / USP17L3 / USP17L30 / USP17L4 / USP17L5 / USP17L7 / USP17L8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 103415072
Gene end: 103419880
  
Corresponding Affymetrix probe sets: 10555789 (MoGene1.0st)   1420773_at (Mouse Genome 430 2.0 Array)   1422229_at (Mouse Genome 430 2.0 Array)   1450547_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078323
Ensembl peptide - ENSMUSP00000102505
NCBI entrez gene - 13532     See in Manteia.
MGI - MGI:107698
RefSeq - NM_010089
RefSeq Peptide - NP_034219
swissprot - G5E8I7
Ensembl - ENSMUSG00000058976
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A6NCW0ENSG00000225327Homo sapiens
 A6NCW7ENSG00000236125Homo sapiens
 A8MUK1ENSG00000227140Homo sapiens
 C9J2P7ENSG00000223569Homo sapiens
 C9JJH3ENSG00000231396Homo sapiens
 C9JLJ4ENSG00000232399Homo sapiens
 C9JPN9ENSG00000227551Homo sapiens
 C9JVI0ENSG00000233136Homo sapiens
 D6R901ENSG00000249811Homo sapiens
 D6R9N7ENSG00000250844Homo sapiens
 D6RA61ENSG00000248933Homo sapiens
 D6RBM5ENSG00000250913Homo sapiens
 D6RBQ6ENSG00000249104Homo sapiens
 D6RCP7ENSG00000248920Homo sapiens
 D6RJB6ENSG00000250745Homo sapiens
 P0C7H9ENSG00000226430Homo sapiens
 P0C7I0ENSG00000237038Homo sapiens
 Q0WX57ENSG00000228856Homo sapiens
 Q0WX57ENSG00000231051Homo sapiens
 Q0WX57ENSG00000229579Homo sapiens
 Q0WX57ENSG00000230430Homo sapiens
 Q0WX57ENSG00000232264Homo sapiens
 Q0WX57ENSG00000231637Homo sapiens
 Q0WX57ENSG00000235780Homo sapiens
 Q6R6M4ENSG00000223443Homo sapiens
 Q7RTZ2ENSG00000230549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G5E8G2 / Usp17ld / ubiquitin specific peptidase 17-like D / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005732197
Q61068 / Usp17la / ubiquitin specific peptidase 17-like A / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005456886
Usp17le / ubiquitin specific peptidase 17-like E / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000004307382
E9Q9U0 / Usp17lb / ubiquitin specific peptidase 17-like B / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000006236973
Usp42 / B2RQC2 / ubiquitin specific peptidase 42 / Q9H9J4*ENSMUSG0000005130637
Usp36 / B1AQJ2 / ubiquitin specific peptidase 36 / Q9P275*ENSMUSG0000003390932
Usp3 / Q91W36 / ubiquitin specific peptidase 3 / Q9Y6I4*ENSMUSG0000003237618
Usp22 / Q5DU02 / ubiquitin specific peptidase 22 / Q9UPT9*ENSMUSG0000004250618
Q8CEG8 / Usp27x / ubiquitin specific peptidase 27, X chromosome / A6NNY8* / ubiquitin specific peptidase 27, X-linked*ENSMUSG0000004626918
Usp49 / Q6P9L4 / ubiquitin specific peptidase 49 / Q70CQ1*ENSMUSG0000009011518
Usp51 / B1AY15 / ubiquitin specific protease 51 / Q70EK9* / ubiquitin specific peptidase 51*ENSMUSG0000006721517
Usp44 / Q8C2S0 / ubiquitin specific peptidase 44 / Q9H0E7*ENSMUSG000000200207


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0012119 increased trophectoderm apoptosis "increase in the number of trophectoderm cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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