ENSMUSG00000042506


Mus musculus

Features
Gene ID: ENSMUSG00000042506
  
Biological name :Usp22
  
Synonyms : Q5DU02 / ubiquitin specific peptidase 22 / Usp22
  
Possible biological names infered from orthology : Q9UPT9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61151785
Gene end: 61175055
  
Corresponding Affymetrix probe sets: 10386636 (MoGene1.0st)   1437151_at (Mouse Genome 430 2.0 Array)   1456043_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041263
Ensembl peptide - ENSMUSP00000135872
NCBI entrez gene - 216825     See in Manteia.
MGI - MGI:2144157
RefSeq - NM_001004143
RefSeq Peptide - NP_001004143
swissprot - H3BLQ1
swissprot - Q5DU02
Ensembl - ENSMUSG00000042506
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp22ENSDARG00000040407Danio rerio
 USP22ENSG00000124422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CEG8 / Usp27x / ubiquitin specific peptidase 27, X chromosome / A6NNY8* / ubiquitin specific peptidase 27, X-linked*ENSMUSG0000004626966
Usp51 / B1AY15 / ubiquitin specific protease 51 / Q70EK9* / ubiquitin specific peptidase 51*ENSMUSG0000006721565
Usp49 / Q6P9L4 / ubiquitin specific peptidase 49 / Q70CQ1*ENSMUSG0000009011527
Usp3 / Q91W36 / ubiquitin specific peptidase 3 / Q9Y6I4*ENSMUSG0000003237626
Usp42 / B2RQC2 / ubiquitin specific peptidase 42 / Q9H9J4*ENSMUSG0000005130621
Usp36 / B1AQJ2 / ubiquitin specific peptidase 36 / Q9P275*ENSMUSG0000003390921
Q61068 / Usp17la / ubiquitin specific peptidase 17-like A / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005456819
Usp17le / ubiquitin specific peptidase 17-like E / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000004307319
E9Q9U0 / Usp17lb / ubiquitin specific peptidase 17-like B / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000006236919
Usp17lc / ubiquitin specific peptidase 17-like C / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000005897618
G5E8G2 / Usp17ld / ubiquitin specific peptidase 17-like D / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005732118
Usp44 / Q8C2S0 / ubiquitin specific peptidase 44 / Q9H0E7*ENSMUSG0000002002015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IC
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016574 histone ubiquitination IEA
 biological_processGO:0016578 histone deubiquitination IEA
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 cellular_componentGO:0000124 SAGA complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0070461 SAGA-type complex IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mis18atm1.1Kiik/Mis18atm1.2Kiik
Genetic Background: B6(129S)-Mis18atm1.1Kiik/Mis18atm1.2Kiik

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mis18atm1.1Kiik/Mis18atm1.2Kiik
Genetic Background: B6(129S)-Mis18atm1.1Kiik/Mis18atm1.2Kiik

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mis18atm1.1Kiik/Mis18atm1.2Kiik
Genetic Background: B6(129S)-Mis18atm1.1Kiik/Mis18atm1.2Kiik

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0013485 increased Paneth cell number "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Mis18atm1.1Kiik/Mis18atm1.2Kiik
Genetic Background: B6(129S)-Mis18atm1.1Kiik/Mis18atm1.2Kiik

 MP:0013794 abnormal intestinal villus goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the villi of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
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Allelic Composition: Whrntm1b(EUCOMM)Wtsi/Whrntm1b(EUCOMM)Wtsi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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