ENSMUSG00000051306


Mus musculus

Features
Gene ID: ENSMUSG00000051306
  
Biological name :Usp42
  
Synonyms : B2RQC2 / ubiquitin specific peptidase 42 / Usp42
  
Possible biological names infered from orthology : Q9H9J4
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 143710325
Gene end: 143732280
  
Corresponding Affymetrix probe sets: 10535477 (MoGene1.0st)   1434782_at (Mouse Genome 430 2.0 Array)   1459934_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053955
NCBI entrez gene - 76800     See in Manteia.
MGI - MGI:1924050
RefSeq - NM_029749
RefSeq - XM_006504754
RefSeq Peptide - NP_084025
swissprot - B2RQC2
Ensembl - ENSMUSG00000051306
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp42ENSDARG00000077300Danio rerio
 USP42ENSGALG00000003378Gallus gallus
 USP42ENSG00000106346Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp36 / B1AQJ2 / ubiquitin specific peptidase 36 / Q9P275*ENSMUSG0000003390927
Usp17le / ubiquitin specific peptidase 17-like E / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000004307315
Q61068 / Usp17la / ubiquitin specific peptidase 17-like A / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005456815
Usp17lc / ubiquitin specific peptidase 17-like C / C9JJH3* / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / A6NCW7* / D6RBQ6* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* ...ENSMUSG0000005897615
G5E8G2 / Usp17ld / ubiquitin specific peptidase 17-like D / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000005732115
E9Q9U0 / Usp17lb / ubiquitin specific peptidase 17-like B / C9JLJ4* / A6NCW0* / C9JPN9* / C9JVI0* / D6R901* / D6R9N7* / D6RA61* / D6RBM5* / A6NCW7* / D6RCP7* / D6RJB6* / P0C7H9* / P0C7I0* /...ENSMUSG0000006236914
Usp3 / Q91W36 / ubiquitin specific peptidase 3 / Q9Y6I4*ENSMUSG000000323769
Usp49 / Q6P9L4 / ubiquitin specific peptidase 49 / Q70CQ1*ENSMUSG000000901159
Usp51 / B1AY15 / ubiquitin specific protease 51 / Q70EK9* / ubiquitin specific peptidase 51*ENSMUSG000000672158
Q8CEG8 / Usp27x / ubiquitin specific peptidase 27, X chromosome / A6NNY8* / ubiquitin specific peptidase 27, X-linked*ENSMUSG000000462698
Usp22 / Q5DU02 / ubiquitin specific peptidase 22 / Q9UPT9*ENSMUSG000000425068
Usp44 / Q8C2S0 / ubiquitin specific peptidase 44 / Q9H0E7*ENSMUSG000000200204


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
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Allelic Composition: Usp42tm2a(EUCOMM)Wtsi/Usp42tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex






 

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