ENSG00000124422


Homo sapiens

Features
Gene ID: ENSG00000124422
  
Biological name :USP22
  
Synonyms : Q9UPT9 / ubiquitin specific peptidase 22 / USP22
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 20999593
Gene end: 21043760
  
Corresponding Affymetrix probe sets: 200083_at (Human Genome U133 Plus 2.0 Array)   216957_at (Human Genome U133 Plus 2.0 Array)   216964_at (Human Genome U133 Plus 2.0 Array)   220861_at (Human Genome U133 Plus 2.0 Array)   220862_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468748
Ensembl peptide - ENSP00000464499
Ensembl peptide - ENSP00000468457
Ensembl peptide - ENSP00000261497
Ensembl peptide - ENSP00000440950
Ensembl peptide - ENSP00000464398
NCBI entrez gene - 23326     See in Manteia.
OMIM - 612116
RefSeq - XM_005256575
RefSeq - NM_015276
RefSeq Peptide - NP_056091
swissprot - K7ERX6
swissprot - K7ESK0
swissprot - J3QRV6
swissprot - Q9UPT9
swissprot - J3QS30
Ensembl - ENSG00000124422
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp22ENSDARG00000040407Danio rerio
 Usp22ENSMUSG00000042506Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP51 / Q70EK9 / ubiquitin specific peptidase 51ENSG0000024774671
A6NNY8 / USP27X / ubiquitin specific peptidase 27, X-linkedENSG0000027382067
USP44 / Q9H0E7 / ubiquitin specific peptidase 44ENSG0000013601429
USP49 / Q70CQ1 / ubiquitin specific peptidase 49ENSG0000016466327
USP3 / Q9Y6I4 / ubiquitin specific peptidase 3ENSG0000014045526
D6RBQ6 / USP17L17 / ubiquitin specific peptidase 17-like family member 17ENSG0000024910421
USP36 / Q9P275 / ubiquitin specific peptidase 36ENSG0000005548321
USP42 / Q9H9J4 / ubiquitin specific peptidase 42ENSG0000010634621
C9JLJ4 / USP17L13 / ubiquitin specific peptidase 17-like family member 13ENSG0000023239921
C9JVI0 / USP17L11 / ubiquitin specific peptidase 17-like family member 11ENSG0000023313620
Q0WX57 / USP17L24 / ubiquitin specific peptidase 17-like family member 24ENSG0000023226420
Q6R6M4 / USP17L2 / ubiquitin specific peptidase 17-like family member 2ENSG0000022344320
A8MUK1 / USP17L5 / ubiquitin specific peptidase 17-like family member 5ENSG0000022714020
Q7RTZ2 / USP17L1 / ubiquitin specific peptidase 17-like family member 1ENSG0000023054920
Q0WX57 / USP17L28 / ubiquitin specific peptidase 17-like family member 28ENSG0000023105120
D6RA61 / USP17L22 / ubiquitin specific peptidase 17-like family member 22ENSG0000024893320
D6RCP7 / USP17L19 / ubiquitin specific peptidase 17-like family member 19ENSG0000024892020
Q0WX57 / USP17L29 / ubiquitin specific peptidase 17-like family member 29ENSG0000023163720
Q0WX57 / USP17L26 / ubiquitin specific peptidase 17-like family member 26ENSG0000022957920
A6NCW0 / USP17L3 / ubiquitin specific peptidase 17-like family member 3ENSG0000022532720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching NAS
 biological_processGO:0016574 histone ubiquitination IDA
 biological_processGO:0016578 histone deubiquitination IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 cellular_componentGO:0000124 SAGA complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0070461 SAGA-type complex IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IMP
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr