ENSGALG00000009971


Gallus gallus

Features
Gene ID: ENSGALG00000009971
  
Biological name :CDC20
  
Synonyms : CDC20 / cell division cycle 20
  
Possible biological names infered from orthology : Cell division cycle / Q12834 / Q9JJ66
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 19746944
Gene end: 19752319
  
Corresponding Affymetrix probe sets: GgaAffx.13051.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059805
Ensembl peptide - ENSGALP00000016189
NCBI entrez gene - 424563     See in Manteia.
RefSeq - NM_001006536
RefSeq Peptide - NP_001006536
swissprot - Q5ZI36
swissprot - A0A1L1RM12
Ensembl - ENSGALG00000009971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc20ENSDARG00000100741Danio rerio
 CDC20ENSG00000117399Homo sapiens
 Cdc20ENSMUSG00000006398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZR1 / fizzy-related protein homolog / Q9R1K5* / Q9UM11* / fizzy and cell division cycle 20 related 1*ENSGALG0000000208535
CDC20B / cell division cycle 20B / Q86Y33*ENSGALG0000004618829


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family
 IPR033187  Cell division cycle protein 20 homologue


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007064 mitotic sister chromatid cohesion IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IEA
 biological_processGO:0040020 regulation of meiotic nuclear division IEA
 biological_processGO:0090129 positive regulation of synapse maturation IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003085 CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*  / complex / reaction
 ENSGALG00000006110 PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000009681 BUB3 / BUB3, mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / complex / reaction
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000011400 USP44 / ubiquitin specific peptidase 44 / Q8C2S0* / Q9H0E7*  / complex
 ENSGALG00000036892 BUB1B / BUB1 mitotic checkpoint serine/threonine kinase B / O60566* / Q9Z1S0* / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex






 

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