ENSGALG00000003085


Gallus gallus

Features
Gene ID: ENSGALG00000003085
  
Biological name :CDK1
  
Synonyms : CDK1 / cyclin-dependent kinase 1
  
Possible biological names infered from orthology : P06493 / P11440
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 8734947
Gene end: 8742973
  
Corresponding Affymetrix probe sets: Gga.726.2.S1_a_at (Chicken Array)   GgaAffx.1944.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004867
Ensembl peptide - ENSGALP00000064406
NCBI entrez gene - 396252     See in Manteia.
RefSeq - XM_015288064
RefSeq - NM_205314
RefSeq - XM_015288063
RefSeq Peptide - NP_990645
swissprot - F1NBD7
Ensembl - ENSGALG00000003085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk1ENSDARG00000087554Danio rerio
 CDK1ENSG00000170312Homo sapiens
 Cdk1ENSMUSG00000019942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK2 / cyclin-dependent kinase 2 / P24941* / P97377*ENSGALG0000003269964
CDK3 / Q00526* / Cdk3-ps* / cyclin dependent kinase 3*ENSGALG0000000846262
CDK3* / Q00526* / Cdk3-ps* / cyclin dependent kinase 3*ENSGALG0000003853562
CDK6 / cyclin dependent kinase 6 / Q00534* / Q64261*ENSGALG0000000947644
CDK10 / cyclin dependent kinase 10 / Q15131* / Q3UMM4*ENSGALG0000000614442
CDK11A / cell division protein kinase 11 / Q9UQ88* / CDK11B* / P24788* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B* / Mus musculus cyclin-dependent kinase 11B (Cdk11b), tr...ENSGALG0000000138240


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0034501 protein localization to kinetochore IEA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044772 mitotic cell cycle phase transition IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0097125 cyclin B1-CDK1 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0035173 histone kinase activity IEA
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity IEA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
Regulation of TP53 Degradation
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009681 BUB3 / BUB3, mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / reaction / complex
 ENSGALG00000009971 CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *  / reaction / complex
 ENSGALG00000001907 WAPL / wings apart-like protein homolog / Q65Z40* / Q7Z5K2* / WAPL cohesin release factor*  / reaction
 ENSGALG00000004161 CCNB2 / P29332 / G2/mitotic-specific cyclin-B2 / O95067* / P30276* / cyclin B2*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000036892 BUB1B / BUB1 mitotic checkpoint serine/threonine kinase B / O60566* / Q9Z1S0* / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta *  / complex / reaction
 ENSGALG00000031448 MAPK6 / Q5F3W3 / Mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction
 ENSGALG00000017070 PDS5B / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / reaction
 ENSGALG00000015641 CCNH / cyclin H / P51946* / Q61458*  / reaction
 ENSGALG00000011910 MNAT1 / MNAT1, CDK activating kinase assembly factor / P51948* / P51949* / CDK-activating kinase assembly factor MAT1 *  / reaction
 ENSGALG00000014790 CDK7 / cyclin dependent kinase 7 / P50613* / Q03147*  / reaction
 ENSGALG00000038469 CDC25A / cell division cycle 25A / P30304* / P48964* / M-phase inducer phosphatase 1 *  / reaction






 

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