ENSGALG00000032699


Gallus gallus

Features
Gene ID: ENSGALG00000032699
  
Biological name :CDK2
  
Synonyms : CDK2 / cyclin-dependent kinase 2
  
Possible biological names infered from orthology : P24941 / P97377
  
Species: Gallus gallus
  
Chr. number: 33
Strand: 1
Band:
Gene start: 617930
Gene end: 620154
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000056613
NCBI entrez gene - 100529062     See in Manteia.
RefSeq - NM_001199857
RefSeq Peptide - NP_001186786
swissprot - A0A1D5PUK9
Ensembl - ENSGALG00000032699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk2ENSDARG00000026577Danio rerio
 CDK2ENSG00000123374Homo sapiens
 Cdk2ENSMUSG00000025358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK3* / Q00526* / Cdk3-ps* / cyclin dependent kinase 3*ENSGALG0000003853578
CDK3 / Q00526* / Cdk3-ps* / cyclin dependent kinase 3*ENSGALG0000000846278
CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*ENSGALG0000000308565
CDK6 / cyclin dependent kinase 6 / Q00534* / Q64261*ENSGALG0000000947648
CDK11A / cell division protein kinase 11 / Q9UQ88* / CDK11B* / P24788* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B* / Mus musculus cyclin-dependent kinase 11B (Cdk11b), tr...ENSGALG0000000138244
CDK10 / cyclin dependent kinase 10 / Q15131* / Q3UMM4*ENSGALG0000000614443


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032298 positive regulation of DNA-dependent DNA replication initiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060968 regulation of gene silencing IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0000805 X chromosome IEA
 cellular_componentGO:0000806 Y chromosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0097123 cyclin A1-CDK2 complex IEA
 cellular_componentGO:0097124 cyclin A2-CDK2 complex IEA
 cellular_componentGO:0097134 cyclin E1-CDK2 complex IEA
 cellular_componentGO:0097135 cyclin E2-CDK2 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0035173 histone kinase activity IEA
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr