ENSGALG00000001907


Gallus gallus

Features
Gene ID: ENSGALG00000001907
  
Biological name :WAPL
  
Synonyms : WAPL / wings apart-like protein homolog
  
Possible biological names infered from orthology : Q65Z40 / Q7Z5K2 / WAPL cohesin release factor
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 2236566
Gene end: 2359786
  
Corresponding Affymetrix probe sets: Gga.11751.1.S1_at (Chicken Array)   Gga.11914.1.S1_at (Chicken Array)   Gga.11914.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044235
Ensembl peptide - ENSGALP00000058111
Ensembl peptide - ENSGALP00000002944
NCBI entrez gene - 423608     See in Manteia.
RefSeq - XM_015287978
RefSeq - NM_001199511
RefSeq - XM_015287975
RefSeq - XM_015287976
RefSeq - XM_015287977
RefSeq Peptide - NP_001186440
swissprot - A0A1D5PYQ6
swissprot - F1NF28
swissprot - A0A1D5NV62
Ensembl - ENSGALG00000001907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 waplaENSDARG00000044144Danio rerio
 waplbENSDARG00000029768Danio rerio
 WAPLENSG00000062650Homo sapiens
 WaplENSMUSG00000041408Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012502  WAPL domain
 IPR016024  Armadillo-type fold
 IPR022771  Wings apart-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007064 mitotic sister chromatid cohesion IBA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0045132 meiotic chromosome segregation IBA
 biological_processGO:0045875 negative regulation of sister chromatid cohesion IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051983 regulation of chromosome segregation IEA
 biological_processGO:0060623 regulation of chromosome condensation IBA
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:0071922 regulation of cohesin loading IBA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008278 cohesin complex IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000017070 PDS5B / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / complex / reaction
 ENSGALG00000001907 WAPL / wings apart-like protein homolog / Q65Z40* / Q7Z5K2* / WAPL cohesin release factor*  / reaction
 ENSGALG00000003085 CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction
 ENSGALG00000004161 CCNB2 / P29332 / G2/mitotic-specific cyclin-B2 / O95067* / P30276* / cyclin B2*  / reaction
 ENSGALG00000006110 PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*  / reaction






 

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