ENSG00000062650


Homo sapiens

Features
Gene ID: ENSG00000062650
  
Biological name :WAPL
  
Synonyms : Q7Z5K2 / WAPL / WAPL cohesin release factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q23.2
Gene start: 86435256
Gene end: 86521815
  
Corresponding Affymetrix probe sets: 1554441_a_at (Human Genome U133 Plus 2.0 Array)   212264_s_at (Human Genome U133 Plus 2.0 Array)   212267_at (Human Genome U133 Plus 2.0 Array)   217218_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263070
Ensembl peptide - ENSP00000298767
Ensembl peptide - ENSP00000361145
Ensembl peptide - ENSP00000481451
NCBI entrez gene - 23063     See in Manteia.
OMIM - 610754
RefSeq - XM_017015981
RefSeq - NM_001318328
RefSeq - NM_015045
RefSeq - XM_011539548
RefSeq - XM_017015979
RefSeq - XM_017015980
RefSeq Peptide - NP_001305257
RefSeq Peptide - NP_055860
swissprot - Q8WVX6
swissprot - F6QZY1
swissprot - Q7Z5K2
Ensembl - ENSG00000062650
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 waplaENSDARG00000044144Danio rerio
 waplbENSDARG00000029768Danio rerio
 WAPLENSGALG00000001907Gallus gallus
 WaplENSMUSG00000041408Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR012502  WAPL domain
 IPR016024  Armadillo-type fold
 IPR022771  Wings apart-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007064 mitotic sister chromatid cohesion IBA
 biological_processGO:0008156 negative regulation of DNA replication IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0035562 negative regulation of chromatin binding IMP
 biological_processGO:0045132 meiotic chromosome segregation IBA
 biological_processGO:0045875 negative regulation of sister chromatid cohesion IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051983 regulation of chromosome segregation IEA
 biological_processGO:0060623 regulation of chromosome condensation IBA
 biological_processGO:0071168 protein localization to chromatin IMP
 biological_processGO:0071922 regulation of cohesin loading IMP
 cellular_componentGO:0000775 chromosome, centromeric region TAS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008278 cohesin complex IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129933 MAU2 / Q9Y6X3 / MAU2 sister chromatid cohesion factor  / complex / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000146670 CDCA5 / Q96FF9 / cell division cycle associated 5  / complex / reaction
 ENSG00000121892 PDS5A / Q29RF7 / PDS5 cohesin associated factor A  / complex / reaction
 ENSG00000062650 WAPL / Q7Z5K2 / WAPL cohesin release factor  / reaction
 ENSG00000083642 PDS5B / Q9NTI5 / PDS5 cohesin associated factor B  / complex / reaction
 ENSG00000164190 NIPBL / Q6KC79 / NIPBL, cohesin loading factor  / reaction / complex
 ENSG00000171320 ESCO2 / Q56NI9 / establishment of sister chromatid cohesion N-acetyltransferase 2  / reaction
 ENSG00000164754 RAD21 / O60216 / RAD21 cohesin complex component  / reaction
 ENSG00000157456 CCNB2 / O95067 / cyclin B2  / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000141446 ESCO1 / Q5FWF5 / establishment of sister chromatid cohesion N-acetyltransferase 1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction






 

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