ENSG00000166851


Homo sapiens

Features
Gene ID: ENSG00000166851
  
Biological name :PLK1
  
Synonyms : P53350 / PLK1 / polo like kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.2
Gene start: 23677656
Gene end: 23690367
  
Corresponding Affymetrix probe sets: 202240_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300093
Ensembl peptide - ENSP00000460084
Ensembl peptide - ENSP00000460266
Ensembl peptide - ENSP00000459688
NCBI entrez gene - 5347     See in Manteia.
OMIM - 602098
RefSeq - NM_005030
RefSeq Peptide - NP_005021
swissprot - P53350
swissprot - I3L2H5
swissprot - I3L309
swissprot - I3L387
Ensembl - ENSG00000166851
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk1ENSDARG00000058471Danio rerio
 PLK1ENSGALG00000006110Gallus gallus
 Plk1ENSMUSG00000030867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLK3 / Q9H4B4 / polo like kinase 3ENSG0000017384640
PLK2 / Q9NYY3 / polo like kinase 2ENSG0000014563239
PLK4 / O00444 / polo like kinase 4ENSG0000014273124
PLK5 / Q496M5 / polo like kinase 5ENSG0000018598814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR033702  Polo-like kinase 1, catalytic domain
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IMP
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0000281 mitotic cytokinesis IDA
 biological_processGO:0001578 microtubule bundle formation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007094 mitotic spindle assembly checkpoint IMP
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016321 female meiosis chromosome segregation IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IMP
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0045143 homologous chromosome segregation IEA
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0051081 nuclear envelope disassembly IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IMP
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0070194 synaptonemal complex disassembly IEA
 biological_processGO:0071168 protein localization to chromatin IDA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IDA
 biological_processGO:0090435 protein localization to nuclear envelope IMP
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1900182 positive regulation of protein localization to nucleus TAS
 biological_processGO:1901673 regulation of mitotic spindle assembly IDA
 biological_processGO:1902749 regulation of cell cycle G2/M phase transition TAS
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity TAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0000942 condensed nuclear chromosome outer kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0051233 spindle midzone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0010997 anaphase-promoting complex binding IPI
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / reaction / complex
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000083642 PDS5B / Q9NTI5 / PDS5 cohesin associated factor B  / reaction
 ENSG00000127564 PKMYT1 / Q99640 / protein kinase, membrane associated tyrosine/threonine 1  / reaction
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction
 ENSG00000146670 CDCA5 / Q96FF9 / cell division cycle associated 5  / reaction
 ENSG00000167461 RAB8A / P61006 / RAB8A, member RAS oncogene family  / reaction
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction
 ENSG00000166483 WEE1 / P30291 / WEE1 G2 checkpoint kinase  / reaction
 ENSG00000121892 PDS5A / Q29RF7 / PDS5 cohesin associated factor A  / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / reaction
 ENSG00000090273 NUDC / Q9Y266 / nuclear distribution C, dynein complex regulator  / reaction
 ENSG00000119638 NEK9 / Q8TD19 / NIMA related kinase 9  / reaction
 ENSG00000137807 KIF23 / Q02241 / kinesin family member 23  / reaction
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / reaction
 ENSG00000123240 OPTN / Q96CV9 / optineurin  / reaction
 ENSG00000062650 WAPL / Q7Z5K2 / WAPL cohesin release factor  / reaction
 ENSG00000112984 KIF20A / O95235 / kinesin family member 20A  / reaction
 ENSG00000111206 FOXM1 / Q08050 / forkhead box M1  / complex / reaction
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / complex / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / complex / reaction
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / reaction / complex
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / complex / reaction
 ENSG00000075218 GTSE1 / Q9NYZ3 / G2 and S-phase expressed 1  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex






 

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