ENSG00000173846


Homo sapiens

Features
Gene ID: ENSG00000173846
  
Biological name :PLK3
  
Synonyms : PLK3 / polo like kinase 3 / Q9H4B4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.1
Gene start: 44800225
Gene end: 44805990
  
Corresponding Affymetrix probe sets: 204958_at (Human Genome U133 Plus 2.0 Array)   215462_at (Human Genome U133 Plus 2.0 Array)   229825_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361275
NCBI entrez gene - 1263     See in Manteia.
OMIM - 602913
RefSeq - NM_004073
RefSeq Peptide - NP_004064
swissprot - Q9H4B4
Ensembl - ENSG00000173846
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk3ENSDARG00000038754Danio rerio
 PLK3ENSGALG00000010129Gallus gallus
 Plk3ENSMUSG00000028680Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLK2 / Q9NYY3 / polo like kinase 2ENSG0000014563250
PLK1 / P53350 / polo like kinase 1ENSG0000016685137
PLK4 / O00444 / polo like kinase 4ENSG0000014273125
PLK5 / Q496M5 / polo like kinase 5ENSG0000018598819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020658  Serine/threonine-protein kinase Plk3
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000302 response to reactive oxygen species IDA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006970 response to osmotic stress IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint TAS
 biological_processGO:0007113 endomitotic cell cycle TAS
 biological_processGO:0009314 response to radiation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IMP
 biological_processGO:0032465 regulation of cytokinesis TAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043491 protein kinase B signaling ISS
 biological_processGO:0044819 mitotic G1/S transition checkpoint ISS
 biological_processGO:0051302 regulation of cell division IDA
 biological_processGO:0090166 Golgi disassembly IDA
 biological_processGO:0090316 positive regulation of intracellular protein transport IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1904716 positive regulation of chaperone-mediated autophagy IDA
 biological_processGO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005795 Golgi stack IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction






 

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