ENSMUSG00000028680


Mus musculus

Features
Gene ID: ENSMUSG00000028680
  
Biological name :Plk3
  
Synonyms : Plk3 / serine/threonine-protein kinase PLK3 isoform 2
  
Possible biological names infered from orthology : polo like kinase 3 / Q9H4B4
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 117128655
Gene end: 117133963
  
Corresponding Affymetrix probe sets: 10515399 (MoGene1.0st)   1434496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076130
Ensembl peptide - ENSMUSP00000120476
NCBI entrez gene - 12795     See in Manteia.
MGI - MGI:109604
RefSeq - NM_001313916
RefSeq - NM_013807
RefSeq Peptide - NP_001300845
RefSeq Peptide - NP_038835
swissprot - Q6P571
swissprot - F6V5S5
Ensembl - ENSMUSG00000028680
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk3ENSDARG00000038754Danio rerio
 PLK3ENSGALG00000010129Gallus gallus
 PLK3ENSG00000173846Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plk2 / P53351 / Serine/threonine-protein kinase PLK2 / Q9NYY3* / polo like kinase 2*ENSMUSG0000002170150
Plk5 / Q4FZD7 / Mus musculus polo like kinase 5 (Plk5), transcript variant 2, mRNA. / Q496M5* / polo like kinase 5*ENSMUSG0000003548638
Plk1 / Q07832 / polo like kinase 1 / P53350*ENSMUSG0000003086737
Plk4 / Q64702 / Serine/threonine-protein kinase PLK4 / O00444* / polo like kinase 4*ENSMUSG0000002575825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020658  Serine/threonine-protein kinase Plk3
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0051302 regulation of cell division IEA
 biological_processGO:0090166 Golgi disassembly IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:1904716 positive regulation of chaperone-mediated autophagy IEA
 biological_processGO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhexPug/Y
Genetic Background: involves: C57BL/6J

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000044201 Cdc25c / P48967 / cell division cycle 25C / P30307*  / reaction






 

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