ENSMUSG00000021701


Mus musculus

Features
Gene ID: ENSMUSG00000021701
  
Biological name :Plk2
  
Synonyms : P53351 / Plk2 / Serine/threonine-protein kinase PLK2
  
Possible biological names infered from orthology : polo like kinase 2 / Q9NYY3
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D2.1
Gene start: 110395046
Gene end: 110400844
  
Corresponding Affymetrix probe sets: 10407126 (MoGene1.0st)   1427005_at (Mouse Genome 430 2.0 Array)   1443780_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022212
NCBI entrez gene - 20620     See in Manteia.
MGI - MGI:1099790
RefSeq - NM_152804
RefSeq Peptide - NP_690017
swissprot - P53351
swissprot - Q548A9
Ensembl - ENSMUSG00000021701
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk2aENSDARG00000090752Danio rerio
 plk2bENSDARG00000019130Danio rerio
 PLK2ENSGALG00000014725Gallus gallus
 PLK2ENSG00000145632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plk3 / serine/threonine-protein kinase PLK3 isoform 2 / Q9H4B4* / polo like kinase 3*ENSMUSG0000002868048
Plk1 / Q07832 / polo like kinase 1 / P53350*ENSMUSG0000003086734
Plk5 / Q4FZD7 / Mus musculus polo like kinase 5 (Plk5), transcript variant 2, mRNA. / Q496M5* / polo like kinase 5*ENSMUSG0000003548633
Plk4 / Q64702 / Serine/threonine-protein kinase PLK4 / O00444* / polo like kinase 4*ENSMUSG0000002575822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046599 regulation of centriole replication IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0061000 negative regulation of dendritic spine development IEA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pik3cgtm1Lste/Pik3cgtm1Lste
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064128 Cenpj / Q569L8 / Centromere protein J / Q9HC77*  / reaction






 

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