ENSMUSG00000064128


Mus musculus

Features
Gene ID: ENSMUSG00000064128
  
Biological name :Cenpj
  
Synonyms : Cenpj / Centromere protein J / Q569L8
  
Possible biological names infered from orthology : Q9HC77
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 56526761
Gene end: 56575425
  
Corresponding Affymetrix probe sets: 10420320 (MoGene1.0st)   1437643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065949
Ensembl peptide - ENSMUSP00000153013
Ensembl peptide - ENSMUSP00000155215
NCBI entrez gene - 219103     See in Manteia.
MGI - MGI:2684927
RefSeq - XM_006518849
RefSeq - NM_001014996
RefSeq - XM_006518847
RefSeq Peptide - NP_001014996
swissprot - Q569L8
Ensembl - ENSMUSG00000064128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cenpjENSDARG00000018121Danio rerio
 CENPJENSGALG00000017148Gallus gallus
 CENPJENSG00000151849Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcp10b / t-complex protein 10bENSMUSG0000005560212
Tcp10c / t-complex protein 10cENSMUSG0000005246911
Tcp10a / t-complex protein 10aENSMUSG0000007132211


Protein motifs (from Interpro)
Interpro ID Name
 IPR009852  T-complex protein 10, C-terminal domain
 IPR026581  T-complex protein 10 family
 IPR033068  Centromere protein J


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0030954 astral microtubule nucleation ISO
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0046427 positive regulation of JAK-STAT cascade ISO
 biological_processGO:0046599 regulation of centriole replication IEA
 biological_processGO:0046785 microtubule polymerization IEA
 biological_processGO:0051298 centrosome duplication IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061511 centriole elongation IEA
 biological_processGO:0098534 centriole assembly IMP
 biological_processGO:1902857 positive regulation of non-motile cilium assembly IMP
 biological_processGO:1903087 mitotic spindle pole body duplication IMP
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding ISO


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm1a(EUCOMM)Wtsi/Cdkn2atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdkn2atm1a(EUCOMM)Wtsi/Wtsi

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1a(EUCOMM)Wtsi/Cdkn2atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdkn2atm1a(EUCOMM)Wtsi/Wtsi

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

Allelic Composition: Cenpjtm1b(EUCOMM)Wtsi/Cenpjtm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprcm2Btlr/Ptprcm2Btlr
Genetic Background: C57BL/6J-Ptprcm2Btlr

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Ptprcm2Btlr/Ptprcm2Btlr
Genetic Background: C57BL/6J-Ptprcm2Btlr

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

Allelic Composition: Cenpjtm1b(EUCOMM)Wtsi/Cenpjtm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1a(EUCOMM)Wtsi/Cdkn2atm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdkn2atm1a(EUCOMM)Wtsi/Wtsi

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0004083 polysyndactyly "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004132 absent embryonic cilia "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004222 synechia "an adhesion of parts, especially involving the iris e.g. attachments of the iris to the trabecular meshwork and peripheral cornea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0004284 abnormal Descemet membrane "any structural abnormality in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane" [MESH:A09.371.060.217.271, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004373 bowed humerus "increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004657 small sacral vertebrae "reduced size of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004708 short lumbar vertebrae "reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0008297 retention of the x-zone "failure of the transient cortical layer juxtaposed to the medulla and the zona reticularis to degenerate after puberty in males or after pregnancy in females" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:3582592]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1a(EUCOMM)Wtsi/Cenpjtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Cenpjtm1a(EUCOMM)Wtsi/Wtsi

 MP:0010865 prenatal growth retardation "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1c(EUCOMM)Wtsi,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

Allelic Composition: Cenpjtm1b(EUCOMM)Wtsi/Cenpjtm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ

 MP:0014164 abnormal ciliary process morphology " any structural anomaly of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; these processes increase in thickness as they advance from the orbiculus ciliaris to the external border of the iris, and together with the folds (plicae) in the furrows between them, constitute the corona ciliaris; ciliary processes produce aqueous humor" [http://www.medilexicon.com/medicaldictionary.php?s=processus+ciliaris]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0030048 sloping forehead "apparently excessive posterior sloping of the forehead in a lateral view" [HP:0000340]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0030167 decreased inner canthal distance "decreased distance between the inner corners (medial canthi) of the eyes where the eyelids meet" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021701 Plk2 / P53351 / Serine/threonine-protein kinase PLK2 / Q9NYY3* / polo like kinase 2*  / reaction






 

1 s.

 
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