ENSG00000145632


Homo sapiens

Features
Gene ID: ENSG00000145632
  
Biological name :PLK2
  
Synonyms : PLK2 / polo like kinase 2 / Q9NYY3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q11.2
Gene start: 58453982
Gene end: 58460260
  
Corresponding Affymetrix probe sets: 201939_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274289
Ensembl peptide - ENSP00000478685
NCBI entrez gene - 10769     See in Manteia.
OMIM - 607023
RefSeq - NM_001252226
RefSeq - NM_006622
RefSeq Peptide - NP_001239155
RefSeq Peptide - NP_006613
swissprot - Q9NYY3
swissprot - A0A024QZV1
swissprot - A0A087WUH9
Ensembl - ENSG00000145632
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk2aENSDARG00000090752Danio rerio
 plk2bENSDARG00000019130Danio rerio
 PLK2ENSGALG00000014725Gallus gallus
 Plk2ENSMUSG00000021701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLK3 / Q9H4B4 / polo like kinase 3ENSG0000017384647
PLK1 / P53350 / polo like kinase 1ENSG0000016685135
PLK4 / O00444 / polo like kinase 4ENSG0000014273122
PLK5 / Q496M5 / polo like kinase 5ENSG0000018598816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007052 mitotic spindle organization IDA
 biological_processGO:0007093 mitotic cell cycle checkpoint ISS
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0007613 memory ISS
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032486 Rap protein signal transduction ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0046599 regulation of centriole replication IMP
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0060292 long term synaptic depression ISS
 biological_processGO:0061000 negative regulation of dendritic spine development IEA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000181163 NPM1 / P06748 / nucleophosmin 1  / reaction
 ENSG00000151849 CENPJ / Q9HC77 / centromere protein J  / reaction






 

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