ENSGALG00000014725


Gallus gallus

Features
Gene ID: ENSGALG00000014725
  
Biological name :PLK2
  
Synonyms : PLK2 / polo like kinase 2
  
Possible biological names infered from orthology : P53351 / Q9NYY3 / Serine/threonine-protein kinase PLK2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 18020074
Gene end: 18025386
  
Corresponding Affymetrix probe sets: Gga.10660.1.S1_s_at (Chicken Array)   Gga.10660.2.S1_at (Chicken Array)   GgaAffx.24493.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023702
NCBI entrez gene - 427150     See in Manteia.
RefSeq - XM_424739
swissprot - F1NB57
Ensembl - ENSGALG00000014725
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk2aENSDARG00000090752Danio rerio
 plk2bENSDARG00000019130Danio rerio
 PLK2ENSG00000145632Homo sapiens
 Plk2ENSMUSG00000021701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLK3 / polo like kinase 3 / Q9H4B4* / serine/threonine-protein kinase PLK3 isoform 2 *ENSGALG0000001012949
PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*ENSGALG0000000611034
PLK4 / polo like kinase 4 / O00444* / Q64702* / Serine/threonine-protein kinase PLK4 *ENSGALG0000001019522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046599 regulation of centriole replication IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000017148 CENPJ / centromere protein J / Q569L8* / Q9HC77*  / reaction






 

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