ENSGALG00000010195


Gallus gallus

Features
Gene ID: ENSGALG00000010195
  
Biological name :PLK4
  
Synonyms : PLK4 / polo like kinase 4
  
Possible biological names infered from orthology : O00444 / Q64702 / Serine/threonine-protein kinase PLK4
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 34604394
Gene end: 34618545
  
Corresponding Affymetrix probe sets: GgaAffx.6413.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016553
Ensembl peptide - ENSGALP00000050097
NCBI entrez gene - 422497     See in Manteia.
RefSeq - XM_015276633
RefSeq - XM_015276632
swissprot - E1C1M7
swissprot - A0A1D5PBG9
Ensembl - ENSGALG00000010195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk4ENSDARG00000004576Danio rerio
 PLK4ENSG00000142731Homo sapiens
 Plk4ENSMUSG00000025758Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLK3 / polo like kinase 3 / Q9H4B4* / serine/threonine-protein kinase PLK3 isoform 2 *ENSGALG0000001012916
PLK2 / polo like kinase 2 / P53351* / Q9NYY3* / Serine/threonine-protein kinase PLK2 *ENSGALG0000001472515
PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*ENSGALG0000000611015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033700  Serine/threonine-protein kinase Plk4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0046601 positive regulation of centriole replication IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IEA
 cellular_componentGO:0001741 XY body IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0098536 deuterosome IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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