ENSDARG00000004576


Danio rerio

Features
Gene ID: ENSDARG00000004576
  
Biological name :plk4
  
Synonyms : plk4 / polo-like kinase 4 (Drosophila)
  
Possible biological names infered from orthology : O00444 / polo like kinase 4 / Q64702 / Serine/threonine-protein kinase PLK4
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 43410753
Gene end: 43428397
  
Corresponding Affymetrix probe sets: Dr.11503.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000043865
NCBI entrez gene - 368390     See in Manteia.
RefSeq - NM_001118892
RefSeq - XM_005158871
RefSeq Peptide - NP_001112364
swissprot - F1RB74
ZFIN ID - ZDB-GENE-030619-14
Ensembl - ENSDARG00000004576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLK4ENSGALG00000010195Gallus gallus
 PLK4ENSG00000142731Homo sapiens
 Plk4ENSMUSG00000025758Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plk3 / polo-like kinase 3 (Drosophila) / Q9H4B4* / polo like kinase 3* / serine/threonine-protein kinase PLK3 isoform 2 *ENSDARG0000003875416
plk2b / polo-like kinase 2b (Drosophila) / PLK2* / Q9NYY3* / P53351* / polo like kinase 2* / Serine/threonine-protein kinase PLK2 *ENSDARG0000001913016
plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*ENSDARG0000005847115
plk2a / polo-like kinase 2a (Drosophila) / PLK2* / Q9NYY3* / polo like kinase 2*ENSDARG0000009075215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033696  Plk4, C-terminal polo-box domain
 IPR033698  Plk4, second cryptic polo-box domain
 IPR033699  Plk4, first cryptic polo-box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007099 centriole replication IEA
 cellular_componentGO:0005814 centriole IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer cilium decreased amount , abnormal
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 ZFA:0000150 pronephric duct pronephric duct cystic , abnormal
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 ZFA:0000152 retina retina photoreceptor cell decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism cell decreased amount , abnormal
whole organism decreased size , abnormal
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 ZFA:0001114 head head melanocyte increased amount , abnormal
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 ZFA:0001115 trunk trunk anterior-posterior axis curved , abnormal
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 ZFA:0001117 post-vent region post-vent region cell apoptotic , abnormal
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 ZFA:0001261 ventricular system ventricular system dilated , abnormal
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 ZFA:0009000 cell cell centriole decreased amount , abnormal
cell mitotic spindle morphology , abnormal
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 ZFA:0009127 photoreceptor cell photoreceptor cell cilium absent , abnormal
photoreceptor cell ciliary basal body absent , abnormal
photoreceptor cell cilium decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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