ENSMUSG00000025758


Mus musculus

Features
Gene ID: ENSMUSG00000025758
  
Biological name :Plk4
  
Synonyms : Plk4 / Q64702 / Serine/threonine-protein kinase PLK4
  
Possible biological names infered from orthology : O00444 / polo like kinase 4
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 40800019
Gene end: 40816883
  
Corresponding Affymetrix probe sets: 10491805 (MoGene1.0st)   1419838_s_at (Mouse Genome 430 2.0 Array)   1426580_at (Mouse Genome 430 2.0 Array)   1452115_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145201
Ensembl peptide - ENSMUSP00000144693
Ensembl peptide - ENSMUSP00000145277
Ensembl peptide - ENSMUSP00000145455
Ensembl peptide - ENSMUSP00000026858
Ensembl peptide - ENSMUSP00000126945
NCBI entrez gene - 20873     See in Manteia.
MGI - MGI:101783
RefSeq - XM_011239968
RefSeq - NM_011495
RefSeq - NM_173169
RefSeq - XM_006500768
RefSeq - XM_006500770
RefSeq Peptide - NP_035625
RefSeq Peptide - NP_775261
swissprot - F6QIM3
swissprot - E9PVH4
swissprot - Q64702
swissprot - E9Q4W7
swissprot - A0A0N4SWB8
Ensembl - ENSMUSG00000025758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plk4ENSDARG00000004576Danio rerio
 PLK4ENSGALG00000010195Gallus gallus
 PLK4ENSG00000142731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plk3 / serine/threonine-protein kinase PLK3 isoform 2 / Q9H4B4* / polo like kinase 3*ENSMUSG0000002868017
Plk2 / P53351 / Serine/threonine-protein kinase PLK2 / Q9NYY3* / polo like kinase 2*ENSMUSG0000002170116
Plk1 / Q07832 / polo like kinase 1 / P53350*ENSMUSG0000003086715
Plk5 / Q4FZD7 / Mus musculus polo like kinase 5 (Plk5), transcript variant 2, mRNA. / Q496M5* / polo like kinase 5*ENSMUSG0000003548615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033696  Plk4, C-terminal polo-box domain
 IPR033698  Plk4, second cryptic polo-box domain
 IPR033699  Plk4, first cryptic polo-box domain
 IPR033700  Serine/threonine-protein kinase Plk4
 IPR036947  POLO box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046601 positive regulation of centriole replication ISS
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 biological_processGO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0098536 deuterosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Plk4m1Lja/Plk4+
Genetic Background: C57BL/6J-Plk4m1Lja

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plk4m1Lja/Plk4+
Genetic Background: C57BL/6J-Plk4m1Lja

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plk4m1Lja/Plk4+
Genetic Background: C57BL/6J-Plk4m1Lja

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plk4m1Lja/Plk4+
Genetic Background: C57BL/6J-Plk4m1Lja

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Kdm5atm1.1Kael/Kdm5atm1.1Kael
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Plk4Gt(XK603)Byg/Plk4m1Lja
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Plk4m1Lja/Plk4m1Lja
Genetic Background: C57BL/6J-Plk4m1Lja

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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