ENSG00000127564


Homo sapiens

Features
Gene ID: ENSG00000127564
  
Biological name :PKMYT1
  
Synonyms : PKMYT1 / protein kinase, membrane associated tyrosine/threonine 1 / Q99640
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 2968024
Gene end: 2980539
  
Corresponding Affymetrix probe sets: 204267_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460868
Ensembl peptide - ENSP00000460598
Ensembl peptide - ENSP00000461330
Ensembl peptide - ENSP00000461628
Ensembl peptide - ENSP00000262300
Ensembl peptide - ENSP00000371675
Ensembl peptide - ENSP00000392855
Ensembl peptide - ENSP00000397739
Ensembl peptide - ENSP00000458545
Ensembl peptide - ENSP00000458842
Ensembl peptide - ENSP00000458943
Ensembl peptide - ENSP00000459123
Ensembl peptide - ENSP00000459880
NCBI entrez gene - 9088     See in Manteia.
OMIM - 602474
RefSeq - XM_011522736
RefSeq - NM_001258450
RefSeq - NM_001258451
RefSeq - NM_004203
RefSeq - NM_182687
RefSeq - XM_011522734
RefSeq - XM_011522735
RefSeq Peptide - NP_001245379
RefSeq Peptide - NP_001245380
RefSeq Peptide - NP_004194
RefSeq Peptide - NP_872629
swissprot - I3L136
swissprot - I3L1H7
swissprot - I3L2S4
swissprot - I3L3P0
swissprot - I3L4Y0
swissprot - I3L4K3
swissprot - Q99640
swissprot - A6NHV6
swissprot - B4DZM6
Ensembl - ENSG00000127564
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkmyt1ENSDARG00000074730Danio rerio
 Pkmyt1ENSMUSG00000023908Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WEE1 / P30291 / WEE1 G2 checkpoint kinaseENSG0000016648326
WEE2 / P0C1S8 / WEE1 homolog 2ENSG0000021410225


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016235  Tyrosine/threonine-protein kinase, Cdc2 inhibitor
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0010923 negative regulation of phosphatase activity IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000157456 CCNB2 / O95067 / cyclin B2  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction






 

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contact: otassy@igbmc.fr