ENSMUSG00000023908


Mus musculus

Features
Gene ID: ENSMUSG00000023908
  
Biological name :Pkmyt1
  
Synonyms : Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase / Pkmyt1 / Q9ESG9
  
Possible biological names infered from orthology : protein kinase, membrane associated tyrosine/threonine 1 / Q99640
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 23726336
Gene end: 23736729
  
Corresponding Affymetrix probe sets: 10442331 (MoGene1.0st)   1418481_at (Mouse Genome 430 2.0 Array)   1438601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024701
NCBI entrez gene - 268930     See in Manteia.
MGI - MGI:2137630
RefSeq - XM_006524311
RefSeq - NM_023058
RefSeq - XM_006524310
RefSeq Peptide - NP_075545
swissprot - Q9ESG9
Ensembl - ENSMUSG00000023908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkmyt1ENSDARG00000074730Danio rerio
 PKMYT1ENSG00000127564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wee1 / P47810 / WEE 1 homolog 1 (S. pombe) / P30291* / WEE1 G2 checkpoint kinase*ENSMUSG0000003101626
Wee2 / Q66JT0 / WEE1 homolog 2 (S. pombe) / P0C1S8* / WEE1 homolog 2*ENSMUSG0000003715922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016235  Tyrosine/threonine-protein kinase, Cdc2 inhibitor
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032218 Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction






 

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