Manteia

ENSMUSG00000041431

Mus musculus

Features

Gene ID:	ENSMUSG00000041431

Biological name :	Ccnb1

Synonyms :	Ccnb1 / G2/mitotic-specific cyclin-B1 / P24860

Possible biological names infered from orthology :	cyclin B1 / P14635

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	D1
Gene start:	100778650
Gene end:	100786570

Corresponding Affymetrix probe sets:	10411739 (MoGene1.0st) 10515836 (MoGene1.0st) 10562637 (MoGene1.0st) 1416076_at (Mouse Genome 430 2.0 Array) 1419943_s_at (Mouse Genome 430 2.0 Array) 1419944_at (Mouse Genome 430 2.0 Array) 1448205_at (Mouse Genome 430 2.0 Array) 1449675_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000071989 Ensembl peptide - ENSMUSP00000088841 Ensembl peptide - ENSMUSP00000133962 NCBI entrez gene - 268697 See in Manteia. MGI - MGI:88302 RefSeq - NM_172301 RefSeq Peptide - NP_758505 swissprot - G3UY65 swissprot - P24860 swissprot - Q3TQW9 swissprot - Q68EM3 Ensembl - ENSMUSG00000041431

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ccnb1	ENSDARG00000051923	Danio rerio
CCNB1	ENSG00000134057	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*	ENSMUSG00000032218	49
Ccna1 / Q61456 / Cyclin-A1 / P78396*	ENSMUSG00000027793	27
Ccnb3 / Q8WWL7* / cyclin B3*	ENSMUSG00000051592	26
Ccna2 / P51943 / Cyclin-A2 / P20248*	ENSMUSG00000027715	26
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*	ENSMUSG00000028212	20
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*	ENSMUSG00000002068	19
Ccno / P0C242 / Cyclin-O / P22674*	ENSMUSG00000042417	19
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*	ENSMUSG00000034165	12
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*	ENSMUSG00000000184	12
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*	ENSMUSG00000070348	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR004367	Cyclin, C-terminal domain
IPR006671	Cyclin, N-terminal
IPR013763	Cyclin-like
IPR036915	Cyclin-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000278	mitotic cell cycle	IEA
biological_process	GO:0001556	oocyte maturation	IEA
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0001933	negative regulation of protein phosphorylation	IEA
biological_process	GO:0006468	protein phosphorylation	IDA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007052	mitotic spindle organization	IEA
biological_process	GO:0007080	mitotic metaphase plate congression	IEA
biological_process	GO:0007283	spermatogenesis	IEA
biological_process	GO:0009612	response to mechanical stimulus	IEA
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0010629	negative regulation of gene expression	IEA
biological_process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IEA
biological_process	GO:0031442	positive regulation of mRNA 3"-end processing	IEA
biological_process	GO:0033129	positive regulation of histone phosphorylation	IEA
biological_process	GO:0042246	tissue regeneration	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	IEA
biological_process	GO:0045787	positive regulation of cell cycle	IDA
biological_process	GO:0045931	positive regulation of mitotic cell cycle	IEA
biological_process	GO:0046680	response to DDT	IEA
biological_process	GO:0048146	positive regulation of fibroblast proliferation	IMP
biological_process	GO:0048565	digestive tract development	IEA
biological_process	GO:0051301	cell division	IEA
biological_process	GO:0051726	regulation of cell cycle	IEA
biological_process	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	IEA
biological_process	GO:0055015	ventricular cardiac muscle cell development	IEA
biological_process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IEA
biological_process	GO:0060623	regulation of chromosome condensation	IEA
biological_process	GO:0071283	cellular response to iron(III) ion	IEA
biological_process	GO:0071398	cellular response to fatty acid	IEA
biological_process	GO:0071407	cellular response to organic cyclic compound	IEA
biological_process	GO:0071456	cellular response to hypoxia	IEA
biological_process	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	IEA
biological_process	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport	IEA
biological_process	GO:2000775	histone H3-S10 phosphorylation involved in chromosome condensation	IDA
cellular_component	GO:0000922	spindle pole	IEA
cellular_component	GO:0000942	condensed nuclear chromosome outer kinetochore	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005759	mitochondrial matrix	IEA
cellular_component	GO:0005813	centrosome	IEA
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0097125	cyclin B1-CDK1 complex	IEA
molecular_function	GO:0005113	patched binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016301	kinase activity	IDA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0035173	histone kinase activity	IEA
molecular_function	GO:0044389	ubiquitin-like protein ligase binding	IEA
molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	IEA

Pathways (from Reactome)

Pathway description

APC/C:Cdc20 mediated degradation of Cyclin B

Regulation of APC/C activators between G1/S and early anaphase

Phosphorylation of the APC/C

Phosphorylation of Emi1

Condensation of Prophase Chromosomes

Resolution of Sister Chromatid Cohesion

Regulation of PLK1 Activity at G2/M Transition

Activation of NIMA Kinases NEK9, NEK6, NEK7

Nuclear Pore Complex (NPC) Disassembly

Depolymerisation of the Nuclear Lamina

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Mitotic Prophase

Cyclin A/B1/B2 associated events during G2/M transition

G2/M DNA replication checkpoint

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

The role of GTSE1 in G2/M progression after G2 checkpoint

Transcriptional regulation by RUNX2

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0009552	urinary bladder obstruction	"any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asf1a^{tm1b(KOMP)Wtsi}/Asf1a⁺ Genetic Background: C57BL/6N-Asf1a^{tm1b(KOMP)Wtsi}/J
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Zp3^tm1Pmw/Zp3^tm1Pmw Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cbx2^{tm1b(KOMP)Wtsi}/Cbx2⁺ Genetic Background: C57BL/6N-Cbx2^{tm1b(KOMP)Wtsi}/H
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Cbx2^{tm1b(KOMP)Wtsi}/Cbx2⁺ Genetic Background: C57BL/6N-Cbx2^{tm1b(KOMP)Wtsi}/H
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Cbx2^{tm1b(KOMP)Wtsi}/Cbx2⁺ Genetic Background: C57BL/6N-Cbx2^{tm1b(KOMP)Wtsi}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000006398	Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*	/ reaction / complex
ENSMUSG00000019942	Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*	/ complex / reaction
ENSMUSG00000023908	Pkmyt1 / Q9ESG9 / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase / Q99640* / protein kinase, membrane associated tyrosine/threonine 1*	/ reaction
ENSMUSG00000021103	Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*	/ reaction
ENSMUSG00000021548	Ccnh / Q61458 / Cyclin-H / P51946*	/ reaction
ENSMUSG00000027330	Cdc25b / P30306 / M-phase inducer phosphatase 2 / P30305* / cell division cycle 25B*	/ reaction
ENSMUSG00000031016	Wee1 / P47810 / WEE 1 homolog 1 (S. pombe) / P30291* / WEE1 G2 checkpoint kinase*	/ reaction
ENSMUSG00000066306	Numa1 / E9Q7G0 / Nuclear mitotic apparatus protein 1 / Q14980*	/ reaction
ENSMUSG00000031885	Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*	/ reaction
ENSMUSG00000020235	Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*	/ reaction
ENSMUSG00000034021	Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*	/ reaction
ENSMUSG00000028063	Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*	/ reaction
ENSMUSG00000041408	Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*	/ reaction
ENSMUSG00000041229	Phf8 / Q80TJ7 / Histone lysine demethylase PHF8 / Q9UPP1* / PHD finger protein 8*	/ reaction
ENSMUSG00000060981	P62806 / Hist1h4h / Histone H4	/ reaction
ENSMUSG00000020593	Lpin1 / Mus musculus lipin 1 (Lpin1), transcript variant 4, mRNA. / Q14693* / lipin 1*	/ reaction
ENSMUSG00000034290	Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*	/ reaction
ENSMUSG00000039153	Runx2 / Q08775 / runt related transcription factor 2 / Q13950*	/ reaction
ENSMUSG00000024791	Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*	/ reaction
ENSMUSG00000022070	Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*	/ reaction
ENSMUSG00000029202	Pds5a / PDS5 cohesin associated factor A / Q29RF7*	/ reaction
ENSMUSG00000019773	Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*	/ reaction
ENSMUSG00000047281	Sfn / O70456 / stratifin / P31947*	/ reaction / complex
ENSMUSG00000044201	Cdc25c / P48967 / cell division cycle 25C / P30307*	/ reaction
ENSMUSG00000069089	Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*	/ reaction
ENSMUSG00000032477	Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr