ENSMUSG00000066306


Mus musculus

Features
Gene ID: ENSMUSG00000066306
  
Biological name :Numa1
  
Synonyms : E9Q7G0 / Nuclear mitotic apparatus protein 1 / Numa1
  
Possible biological names infered from orthology : Q14980
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 101934111
Gene end: 102014964
  
Corresponding Affymetrix probe sets: 10555590 (MoGene1.0st)   1423974_at (Mouse Genome 430 2.0 Array)   1423975_s_at (Mouse Genome 430 2.0 Array)   1441090_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126180
Ensembl peptide - ENSMUSP00000081912
Ensembl peptide - ENSMUSP00000147935
Ensembl peptide - ENSMUSP00000148215
Ensembl peptide - ENSMUSP00000148187
Ensembl peptide - ENSMUSP00000148098
NCBI entrez gene - 101706     See in Manteia.
MGI - MGI:2443665
RefSeq - XM_006507178
RefSeq - XM_006507170
RefSeq - XM_006507171
RefSeq - XM_006507172
RefSeq - XM_006507173
RefSeq - XM_006507174
RefSeq - XM_006507175
RefSeq - XM_006507177
RefSeq - NM_133947
RefSeq - XM_006507169
RefSeq Peptide - NP_598708
swissprot - A0A1B0GT61
swissprot - A0A1B0GT38
swissprot - E9Q7G0
swissprot - A0A1B0GSW3
swissprot - A0A1B0GSH2
swissprot - F6ZQA3
Ensembl - ENSMUSG00000066306
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 numa1ENSDARG00000102483Danio rerio
 NUMA1ENSGALG00000001258Gallus gallus
 NUMA1ENSG00000137497Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026650  Nuclear mitotic apparatus protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0030953 astral microtubule organization IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0032388 positive regulation of intracellular transport IEA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051798 positive regulation of hair follicle development IMP
 biological_processGO:0051984 positive regulation of chromosome segregation IEA
 biological_processGO:0055048 anastral spindle assembly IEA
 biological_processGO:0060236 regulation of mitotic spindle organization IEA
 biological_processGO:0090235 regulation of metaphase plate congression IEA
 biological_processGO:1902365 positive regulation of protein localization to spindle pole body IEA
 biological_processGO:1902846 positive regulation of mitotic spindle elongation IEA
 biological_processGO:1904778 positive regulation of protein localization to cell cortex IEA
 biological_processGO:1905820 positive regulation of chromosome separation IEA
 biological_processGO:1905832 positive regulation of spindle assembly IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031616 spindle pole centrosome IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 cellular_componentGO:0036449 microtubule minus-end IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0055028 cortical microtubule IEA
 cellular_componentGO:0061673 mitotic spindle astral microtubule IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0097427 microtubule bundle IEA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 cellular_componentGO:0097575 lateral cell cortex IMP
 cellular_componentGO:0099738 cell cortex region IEA
 cellular_componentGO:1905720 cytoplasmic microtubule bundle IEA
 cellular_componentGO:1990023 mitotic spindle midzone IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051010 microtubule plus-end binding IEA
 molecular_functionGO:0051011 microtubule minus-end binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Recruitment of NuMA to mitotic centrosomes
Mitotic Prophase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Cacng1tm1Rgg/Cacng1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cacng1tm1Rgg/Cacng1+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Numa1tm1.2Dwc/Numa1tm1.2Dwc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Cacng1tm1Rgg/Cacng1+
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000066306 Numa1 / E9Q7G0 / Nuclear mitotic apparatus protein 1 / Q14980*  / complex






 

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