ENSG00000137497


Homo sapiens

Features
Gene ID: ENSG00000137497
  
Biological name :NUMA1
  
Synonyms : nuclear mitotic apparatus protein 1 / NUMA1 / Q14980
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 72002864
Gene end: 72080693
  
Corresponding Affymetrix probe sets: 1554663_a_at (Human Genome U133 Plus 2.0 Array)   200747_s_at (Human Genome U133 Plus 2.0 Array)   214250_at (Human Genome U133 Plus 2.0 Array)   214251_s_at (Human Genome U133 Plus 2.0 Array)   235539_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478624
Ensembl peptide - ENSP00000446396
Ensembl peptide - ENSP00000480172
Ensembl peptide - ENSP00000481541
Ensembl peptide - ENSP00000260051
Ensembl peptide - ENSP00000351851
Ensembl peptide - ENSP00000357955
Ensembl peptide - ENSP00000377298
Ensembl peptide - ENSP00000438318
Ensembl peptide - ENSP00000438331
Ensembl peptide - ENSP00000438589
Ensembl peptide - ENSP00000438821
Ensembl peptide - ENSP00000439092
Ensembl peptide - ENSP00000439576
Ensembl peptide - ENSP00000439759
Ensembl peptide - ENSP00000440954
Ensembl peptide - ENSP00000441598
Ensembl peptide - ENSP00000441674
Ensembl peptide - ENSP00000442331
Ensembl peptide - ENSP00000442761
Ensembl peptide - ENSP00000442936
Ensembl peptide - ENSP00000444175
Ensembl peptide - ENSP00000444831
Ensembl peptide - ENSP00000444880
NCBI entrez gene - 4926     See in Manteia.
OMIM - 164009
RefSeq - XM_017017831
RefSeq - NM_001286561
RefSeq - NM_006185
RefSeq - XM_006718564
RefSeq - XM_011545054
RefSeq - XM_011545055
RefSeq - XM_011545056
RefSeq - XM_011545057
RefSeq - XM_011545058
RefSeq - XM_011545059
RefSeq - XM_011545060
RefSeq - XM_011545061
RefSeq - XM_011545062
RefSeq - XM_011545063
RefSeq - XM_011545064
RefSeq - XM_011545065
RefSeq - XM_011545066
RefSeq - XM_017017830
RefSeq Peptide - NP_006176
RefSeq Peptide - NP_001273490
swissprot - A0A024R5M9
swissprot - A0A087WY61
swissprot - F5GWA2
swissprot - F5GWK2
swissprot - F5GZW1
swissprot - F5H068
swissprot - F5H073
swissprot - F5H0Z7
swissprot - F5H1L0
swissprot - F5H2F3
swissprot - F5H3L6
swissprot - F5H4J1
swissprot - F5H4Y4
swissprot - F5H6Y5
swissprot - F5H763
swissprot - F5H7R5
swissprot - F8W6T3
swissprot - K4DIE0
swissprot - H0YFY6
swissprot - Q14980
Ensembl - ENSG00000137497
  
Related genetic diseases (OMIM): 612376 - Leukemia, acute promyelocytic, somatic, 612376
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 numa1ENSDARG00000102483Danio rerio
 NUMA1ENSGALG00000001258Gallus gallus
 Numa1ENSMUSG00000066306Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026650  Nuclear mitotic apparatus protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation ISS
 biological_processGO:0001578 microtubule bundle formation IMP
 biological_processGO:0006997 nucleus organization TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway ISS
 biological_processGO:0030953 astral microtubule organization IMP
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0032388 positive regulation of intracellular transport IMP
 biological_processGO:0045618 positive regulation of keratinocyte differentiation ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051798 positive regulation of hair follicle development ISS
 biological_processGO:0051984 positive regulation of chromosome segregation IMP
 biological_processGO:0055048 anastral spindle assembly IMP
 biological_processGO:0060236 regulation of mitotic spindle organization IMP
 biological_processGO:0090235 regulation of metaphase plate congression IMP
 biological_processGO:1902365 positive regulation of protein localization to spindle pole body IDA
 biological_processGO:1902846 positive regulation of mitotic spindle elongation IMP
 biological_processGO:1904778 positive regulation of protein localization to cell cortex IMP
 biological_processGO:1905820 positive regulation of chromosome separation IMP
 biological_processGO:1905832 positive regulation of spindle assembly IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031616 spindle pole centrosome IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0035371 microtubule plus-end IDA
 cellular_componentGO:0036449 microtubule minus-end IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0055028 cortical microtubule IDA
 cellular_componentGO:0061673 mitotic spindle astral microtubule IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0097427 microtubule bundle IDA
 cellular_componentGO:0097431 mitotic spindle pole IMP
 cellular_componentGO:0097575 lateral cell cortex ISS
 cellular_componentGO:0099738 cell cortex region IDA
 cellular_componentGO:1905720 cytoplasmic microtubule bundle IDA
 cellular_componentGO:1990023 mitotic spindle midzone IDA
 molecular_functionGO:0005198 structural molecule activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008022 protein C-terminus binding IMP
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0035091 phosphatidylinositol binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0051010 microtubule plus-end binding IDA
 molecular_functionGO:0051011 microtubule minus-end binding IDA
 molecular_functionGO:0070840 dynein complex binding IDA
 molecular_functionGO:0097718 disordered domain specific binding IMP


Pathways (from Reactome)
Pathway description
Recruitment of NuMA to mitotic centrosomes
Mitotic Prophase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
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 HP:0004836 Acute promyelocytic leukemia 
Show

 HP:0012135 Abnormality of cells of the granulocytic lineage "An anomaly of cells involved in the formation of a granulocytes, that is, of the `granulocytopoietic cell` (CL:0002191)." [DDD:akelly]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000137497 NUMA1 / Q14980 / nuclear mitotic apparatus protein 1  / complex






 

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