ENSMUSG00000027793


Mus musculus

Features
Gene ID: ENSMUSG00000027793
  
Biological name :Ccna1
  
Synonyms : Ccna1 / Cyclin-A1 / Q61456
  
Possible biological names infered from orthology : P78396
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: C
Gene start: 55045469
Gene end: 55055501
  
Corresponding Affymetrix probe sets: 10498192 (MoGene1.0st)   1449177_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143275
Ensembl peptide - ENSMUSP00000142706
Ensembl peptide - ENSMUSP00000143447
Ensembl peptide - ENSMUSP00000143555
Ensembl peptide - ENSMUSP00000029368
Ensembl peptide - ENSMUSP00000142692
NCBI entrez gene - 12427     See in Manteia.
MGI - MGI:108042
RefSeq - XM_011240003
RefSeq - XM_006500950
RefSeq - XM_006500951
RefSeq - XM_006500952
RefSeq - XM_006500953
RefSeq - XM_006500954
RefSeq - XM_006500955
RefSeq - NM_001305221
RefSeq - NM_007628
RefSeq - XM_006500949
RefSeq Peptide - NP_001292150
RefSeq Peptide - NP_031654
swissprot - A0A0G2JGG4
swissprot - A0A0G2JFR4
swissprot - Q61456
swissprot - A0A0G2JEB5
Ensembl - ENSMUSG00000027793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccna1ENSDARG00000043236Danio rerio
 CCNA1ENSGALG00000017052Gallus gallus
 CCNA1ENSG00000133101Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccna2 / P51943 / Cyclin-A2 / P20248*ENSMUSG0000002771547
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143127
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*ENSMUSG0000003221826
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159226
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*ENSMUSG0000002821220
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*ENSMUSG0000000206819
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241718
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416515
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*ENSMUSG0000000018414
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*ENSMUSG0000007034814


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0097123 cyclin A1-CDK2 complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
G0 and Early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Emx2Pdo/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6

Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccna1tm1Coll/Ccna1tm1Coll
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccna1tm1Coll/Ccna1tm1Coll
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccna1tm1Djw/Ccna1tm1Djw,Ccna2tm1.1Pisc/Ccna2tm1.2Pisc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccna1tm1Coll/Ccna1tm1Coll
Genetic Background: involves: 129S/SvEv * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020708 Psmc5 / P62196 / protease (prosome, macropain) 26S subunit, ATPase 5 / P62195* / proteasome 26S subunit, ATPase 5*  / complex
 ENSMUSG00000030079 P60122 / Ruvbl1 / RuvB-like protein 1 / Q9Y265* / RuvB like AAA ATPase 1*  / complex
 ENSMUSG00000033364 Usp37 / Q8C0R0 / ubiquitin specific peptidase 37 / Q86T82*  / complex






 

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