ENSMUSG00000020708


Mus musculus

Features
Gene ID: ENSMUSG00000020708
  
Biological name :Psmc5
  
Synonyms : P62196 / protease (prosome, macropain) 26S subunit, ATPase 5 / Psmc5
  
Possible biological names infered from orthology : P62195 / proteasome 26S subunit, ATPase 5
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 106256154
Gene end: 106263120
  
Corresponding Affymetrix probe sets: 10382069 (MoGene1.0st)   10338486 (MoGene1.0st)   10339106 (MoGene1.0st)   10340453 (MoGene1.0st)   10340509 (MoGene1.0st)   10340959 (MoGene1.0st)   10341466 (MoGene1.0st)   10342732 (MoGene1.0st)   10342902 (MoGene1.0st)   10343635 (MoGene1.0st)   10344106 (MoGene1.0st)   10344560 (MoGene1.0st)   1415740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021049
Ensembl peptide - ENSMUSP00000138057
NCBI entrez gene - 19184     See in Manteia.
MGI - MGI:105047
RefSeq - NM_008950
RefSeq Peptide - NP_032976
swissprot - P62196
swissprot - Q8K1K2
Ensembl - ENSMUSG00000020708
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmc5ENSDARG00000015315Danio rerio
 PSMC5ENSGALG00000000349Gallus gallus
 PSMC5ENSG00000087191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily
 IPR035261  26S proteasome regulatory subunit 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IBA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0090261 positive regulation of inclusion body assembly IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005675 holo TFIIH complex ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005838 proteasome regulatory particle IDA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031595 nuclear proteasome complex IEA
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0031531 thyrotropin-releasing hormone receptor binding IEA
 molecular_functionGO:0036402 proteasome-activating ATPase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmcesem2Dfel/Hmces+
Genetic Background: involves: 129 * C57BL/6N

 MP:0011624 abnormal sensitization to xenobiotic "anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a xenobiotic" [MGI:csmith]
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Allelic Composition: Hmcesem2Dfel/Hmces+
Genetic Background: involves: 129 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027715 Ccna2 / P51943 / Cyclin-A2 / P20248*  / complex
 ENSMUSG00000027793 Ccna1 / Q61456 / Cyclin-A1 / P78396*  / complex
 ENSMUSG00000030079 P60122 / Ruvbl1 / RuvB-like protein 1 / Q9Y265* / RuvB like AAA ATPase 1*  / complex
 ENSMUSG00000033364 Usp37 / Q8C0R0 / ubiquitin specific peptidase 37 / Q86T82*  / complex






 

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