ENSMUSG00000000184


Mus musculus

Features
Gene ID: ENSMUSG00000000184
  
Biological name :Ccnd2
  
Synonyms : Ccnd2 / G1/S-specific cyclin-D2 / P30280
  
Possible biological names infered from orthology : cyclin D2 / P30279
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 127125162
Gene end: 127152193
  
Corresponding Affymetrix probe sets: 10548105 (MoGene1.0st)   1416122_at (Mouse Genome 430 2.0 Array)   1416123_at (Mouse Genome 430 2.0 Array)   1416124_at (Mouse Genome 430 2.0 Array)   1430127_a_at (Mouse Genome 430 2.0 Array)   1434745_at (Mouse Genome 430 2.0 Array)   1448229_s_at (Mouse Genome 430 2.0 Array)   1455956_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000188
Ensembl peptide - ENSMUSP00000144006
Ensembl peptide - ENSMUSP00000144095
Ensembl peptide - ENSMUSP00000144245
NCBI entrez gene - 12444     See in Manteia.
MGI - MGI:88314
RefSeq - XM_006505460
RefSeq - NM_009829
RefSeq - XM_006505459
RefSeq Peptide - NP_033959
swissprot - P30280
swissprot - Q4FK45
swissprot - Q9D8L9
swissprot - A0A0J9YU51
Ensembl - ENSMUSG00000000184
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnd2aENSDARG00000051748Danio rerio
 ccnd2bENSDARG00000070408Danio rerio
 CCND2ENSGALG00000017283Gallus gallus
 CCND2ENSG00000118971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*ENSMUSG0000007034864
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416562
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*ENSMUSG0000002821224
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*ENSMUSG0000000206823
Ccna2 / P51943 / Cyclin-A2 / P20248*ENSMUSG0000002771521
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241720
Ccna1 / Q61456 / Cyclin-A1 / P78396*ENSMUSG0000002779320
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143118
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*ENSMUSG0000003221818
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159216


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR015451  Cyclin D
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0071481 cellular response to X-ray IMP
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0097129 cyclin D2-CDK4 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Cyclin D associated events in G1
Regulation of RUNX1 Expression and Activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cux1tm2Ejn/Cux1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009718 absent Purkinje cell layer "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: Not Specified

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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