ENSMUSG00000002068


Mus musculus

Features
Gene ID: ENSMUSG00000002068
  
Biological name :Ccne1
  
Synonyms : Ccne1 / G1/S-specific cyclin-E1 / Q61457
  
Possible biological names infered from orthology : cyclin E1 / P24864
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 38097984
Gene end: 38107534
  
Corresponding Affymetrix probe sets: 10562563 (MoGene1.0st)   1416492_at (Mouse Genome 430 2.0 Array)   1441910_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103658
Ensembl peptide - ENSMUSP00000145532
Ensembl peptide - ENSMUSP00000117662
NCBI entrez gene - 12447     See in Manteia.
MGI - MGI:88316
RefSeq - NM_007633
RefSeq Peptide - NP_031659
swissprot - D3Z3N8
swissprot - A0A0U1RNE6
swissprot - Q61457
Ensembl - ENSMUSG00000002068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccne1ENSDARG00000098622Danio rerio
 CCNE1ENSGALG00000004494Gallus gallus
 CCNE1ENSG00000105173Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*ENSMUSG0000002821247
Ccna1 / Q61456 / Cyclin-A1 / P78396*ENSMUSG0000002779320
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143120
Ccna2 / P51943 / Cyclin-A2 / P20248*ENSMUSG0000002771519
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159218
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*ENSMUSG0000003221817
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*ENSMUSG0000007034817
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416516
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*ENSMUSG0000000018416
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241713


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028858  Cyclin E
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0000723 telomere maintenance IGI
 biological_processGO:0006270 DNA replication initiation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007129 synapsis IGI
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IGI
 biological_processGO:1903827 regulation of cellular protein localization IGI
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IPI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0097134 cyclin E1-CDK2 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IDA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response
PTK6 Regulates Cell Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ccne1tm1Jro/Ccne1tm1Jro
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0001711 abnormal placenta 
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Jro/?,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: either: (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J) or (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf6tm1Jino/Traf6tm1Jino
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010173 increased mammary gland epithelium proliferation "increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ccne1tm1Jro/Ccne1tm1Jro
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0010241 abnormal aortic arch development "anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Ccne1tm1Jro/?,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: either: (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J) or (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J)

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ccne1tm1Jro/Ccne1tm1Jro
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / complex / reaction
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex / reaction
 ENSMUSG00000032477 Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*  / reaction
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / reaction






 

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