ENSGALG00000004494


Gallus gallus

Features
Gene ID: ENSGALG00000004494
  
Biological name :CCNE1
  
Synonyms : CCNE1 / G1/S-specific cyclin-E1
  
Possible biological names infered from orthology : cyclin E1 / P24864 / Q61457
  
Species: Gallus gallus
  
Chr. number: 11
Strand: 1
Band:
Gene start: 8570363
Gene end: 8582718
  
Corresponding Affymetrix probe sets: Gga.14522.1.S1_at (Chicken Array)   Gga.2368.1.S1_at (Chicken Array)   GgaAffx.11332.1.S1_at (Chicken Array)   GgaAffx.11332.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007147
NCBI entrez gene - 426117     See in Manteia.
RefSeq - NM_001031358
RefSeq Peptide - NP_001026529
swissprot - F1NQ71
Ensembl - ENSGALG00000004494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccne1ENSDARG00000098622Danio rerio
 CCNE1ENSG00000105173Homo sapiens
 Ccne1ENSMUSG00000002068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNE2 / cyclin E2 / O96020* / Q9Z238* / G1/S-specific cyclin-E2 *ENSGALG0000004079449
CCNB2 / P29332 / G2/mitotic-specific cyclin-B2 / O95067* / P30276* / cyclin B2*ENSGALG0000000416120
CCNA1 / cyclin A1 / P78396* / Q61456*ENSGALG0000001705219
CCNA2 / cyclin-A2 / P20248* / P51943*ENSGALG0000001188119
CCND3 / cyclin D3 / P30281* / P30282* / G1/S-specific cyclin-D3 *ENSGALG0000000348518
CCND2 / P49706 / G1/S-specific cyclin-D2 / P30279* / P30280* / cyclin D2*ENSGALG0000001728318
CCNB3 / Q8WWL7* / cyclin B3*ENSGALG0000002581018
CCND1 / G1/S-specific cyclin-D1 / P24385* / P25322* / cyclin D1*ENSGALG0000000755517
CCNO / cyclin O / P0C242* / P22674*ENSGALG0000002859512


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028858  Cyclin E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0097134 cyclin E1-CDK2 complex IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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