ENSGALG00000040794


Gallus gallus

Features
Gene ID: ENSGALG00000040794
  
Biological name :CCNE2
  
Synonyms : CCNE2 / cyclin E2
  
Possible biological names infered from orthology : G1/S-specific cyclin-E2 / O96020 / Q9Z238
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 126933818
Gene end: 127051805
  
Corresponding Affymetrix probe sets: GgaAffx.11513.1.S1_at (Chicken Array)   GgaAffx.11513.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057815
Ensembl peptide - ENSGALP00000043603
NCBI entrez gene - 420231     See in Manteia.
RefSeq - XM_015282920
RefSeq - NM_001030945
RefSeq - XM_015282919
RefSeq Peptide - NP_001026116
swissprot - Q5ZMH4
swissprot - A0A1D5PXW7
Ensembl - ENSGALG00000040794
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccne2ENSDARG00000098529Danio rerio
 CCNE2ENSG00000175305Homo sapiens
 Ccne2ENSMUSG00000028212Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNE1 / G1/S-specific cyclin-E1 / P24864* / Q61457* / cyclin E1*ENSGALG0000000449449
CCNA1 / cyclin A1 / P78396* / Q61456*ENSGALG0000001705219
CCNB2 / P29332 / G2/mitotic-specific cyclin-B2 / O95067* / P30276* / cyclin B2*ENSGALG0000000416118
CCND2 / P49706 / G1/S-specific cyclin-D2 / P30279* / P30280* / cyclin D2*ENSGALG0000001728317
CCNA2 / cyclin-A2 / P20248* / P51943*ENSGALG0000001188117
CCND3 / cyclin D3 / P30281* / P30282* / G1/S-specific cyclin-D3 *ENSGALG0000000348517
CCNB3 / Q8WWL7* / cyclin B3*ENSGALG0000002581016
CCND1 / G1/S-specific cyclin-D1 / P24385* / P25322* / cyclin D1*ENSGALG0000000755516
CCNO / cyclin O / P0C242* / P22674*ENSGALG0000002859512


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028858  Cyclin E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0097135 cyclin E2-CDK2 complex IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSGALG00000028664 CKS1B / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000022980 CDKN1B / cyclin dependent kinase inhibitor 1B / P46414* / P46527*  / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000038469 CDC25A / cell division cycle 25A / P30304* / P48964* / M-phase inducer phosphatase 1 *  / reaction






 

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