ENSMUSG00000028212


Mus musculus

Features
Gene ID: ENSMUSG00000028212
  
Biological name :Ccne2
  
Synonyms : Ccne2 / G1/S-specific cyclin-E2 / Q9Z238
  
Possible biological names infered from orthology : cyclin E2 / O96020
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 11191351
Gene end: 11204779
  
Corresponding Affymetrix probe sets: 10503264 (MoGene1.0st)   1422535_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029866
Ensembl peptide - ENSMUSP00000103960
Ensembl peptide - ENSMUSP00000130693
NCBI entrez gene - 12448     See in Manteia.
MGI - MGI:1329034
RefSeq - XM_011249913
RefSeq - NM_001037134
RefSeq - NM_001282943
RefSeq - NM_009830
RefSeq - XM_006537573
RefSeq - XM_006537574
RefSeq - XM_006537575
RefSeq Peptide - NP_001032211
RefSeq Peptide - NP_001269872
RefSeq Peptide - NP_033960
swissprot - Q544H6
swissprot - Q9Z238
swissprot - A2API1
Ensembl - ENSMUSG00000028212
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccne2ENSDARG00000098529Danio rerio
 CCNE2ENSGALG00000040794Gallus gallus
 CCNE2ENSG00000175305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*ENSMUSG0000000206848
Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*ENSMUSG0000004143121
Ccna1 / Q61456 / Cyclin-A1 / P78396*ENSMUSG0000002779321
Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*ENSMUSG0000003221820
Ccna2 / P51943 / Cyclin-A2 / P20248*ENSMUSG0000002771519
Ccnb3 / Q8WWL7* / cyclin B3*ENSMUSG0000005159219
Ccnd2 / P30280 / G1/S-specific cyclin-D2 / P30279* / cyclin D2*ENSMUSG0000000018417
Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*ENSMUSG0000003416517
Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*ENSMUSG0000007034816
Ccno / P0C242 / Cyclin-O / P22674*ENSMUSG0000004241715


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028858  Cyclin E
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000723 telomere maintenance IGI
 biological_processGO:0006270 DNA replication initiation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007129 synapsis IGI
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IGI
 biological_processGO:1903827 regulation of cellular protein localization IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0097135 cyclin E2-CDK2 complex IDA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IDA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm2.1Pisc/Ccne1tm2.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010241 abnormal aortic arch development "anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Pisc/Ccne2+
Genetic Background: involves: 129S2/SvPas

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Pisc/Ccne1tm1Pisc,Ccne2tm1Boa/Ccne2tm1Boa
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / reaction
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / reaction / complex
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / reaction / complex
 ENSMUSG00000032477 Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*  / reaction






 

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