ENSMUSG00000054115


Mus musculus

Features
Gene ID: ENSMUSG00000054115
  
Biological name :Skp2
  
Synonyms : Q9Z0Z3 / Skp2 / S-phase kinase-associated protein 2 (p45)
  
Possible biological names infered from orthology : Q13309 / S-phase kinase associated protein 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 9111985
Gene end: 9155425
  
Corresponding Affymetrix probe sets: 10427606 (MoGene1.0st)   1418969_at (Mouse Genome 430 2.0 Array)   1425072_at (Mouse Genome 430 2.0 Array)   1436000_a_at (Mouse Genome 430 2.0 Array)   1437033_a_at (Mouse Genome 430 2.0 Array)   1449293_a_at (Mouse Genome 430 2.0 Array)   1460247_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094225
Ensembl peptide - ENSMUSP00000106215
Ensembl peptide - ENSMUSP00000139997
NCBI entrez gene - 27401     See in Manteia.
MGI - MGI:1351663
RefSeq - XM_011245359
RefSeq - NM_001285980
RefSeq - NM_013787
RefSeq Peptide - NP_001272909
RefSeq Peptide - NP_038815
swissprot - Q569Z9
swissprot - Q9Z0Z3
swissprot - A0A087WQ11
Ensembl - ENSMUSG00000054115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skp2ENSDARG00000004937Danio rerio
 SKP2ENSGALG00000003547Gallus gallus
 SKP2ENSG00000145604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IGI
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051726 regulation of cell cycle IPI
 biological_processGO:0071460 cellular response to cell-matrix adhesion IEA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
Orc1 removal from chromatin
Cyclin D associated events in G1
Regulation of RUNX2 expression and activity
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008755 abnormal immunoglobulin V(D)J recombination "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1.1Desi/Rag2tm1.1Desi
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000056900 Usp13 / Q5BKP2 / ubiquitin specific peptidase 13 (isopeptidase T-3) / Q92995* / ubiquitin specific peptidase 13*  / reaction / complex
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / reaction / complex
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / complex / reaction
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / complex
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / reaction / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / complex / reaction






 

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