ENSMUSG00000005262


Mus musculus

Features
Gene ID: ENSMUSG00000005262
  
Biological name :Ufd1
  
Synonyms : P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Ufd1
  
Possible biological names infered from orthology : Q92890
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 18811779
Gene end: 18835261
  
Corresponding Affymetrix probe sets: 10434233 (MoGene1.0st)   1418087_at (Mouse Genome 430 2.0 Array)   1432367_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128186
Ensembl peptide - ENSMUSP00000133217
Ensembl peptide - ENSMUSP00000132341
Ensembl peptide - ENSMUSP00000131977
Ensembl peptide - ENSMUSP00000130394
Ensembl peptide - ENSMUSP00000005394
Ensembl peptide - ENSMUSP00000111241
NCBI entrez gene - 22230     See in Manteia.
MGI - MGI:109353
RefSeq - XM_006522007
RefSeq - NM_011672
RefSeq - XM_006522005
RefSeq - XM_006522006
RefSeq Peptide - NP_035802
swissprot - E9Q6S9
swissprot - E9Q646
swissprot - E9Q475
swissprot - E9Q0Y6
swissprot - F6SYJ2
swissprot - P70362
Ensembl - ENSMUSG00000005262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ufd1lENSDARG00000010051Danio rerio
 UFD1LENSGALG00000001593Gallus gallus
 UFD1ENSG00000070010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004854  Ubiquitin fusion degradation protein Ufd1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0030970 retrograde protein transport, ER to cytosol ISO
 biological_processGO:0032480 negative regulation of type I interferon production ISS
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0071712 ER-associated misfolded protein catabolic process ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex NAS
 cellular_componentGO:0036501 UFD1-NPL4 complex ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0036435 K48-linked polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000031986 Sprtn / G3X912 / SprT-like domain-containing protein Spartan / Q9H040* / SprT-like N-terminal domain*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / reaction / complex
 ENSMUSG00000039703 Nploc4 / P60670 / Nuclear protein localization / Q8TAT6* / NPL4 homolog, ubiquitin recognition factor*  / complex
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex
 ENSMUSG00000056900 Usp13 / Q5BKP2 / ubiquitin specific peptidase 13 (isopeptidase T-3) / Q92995* / ubiquitin specific peptidase 13*  / complex / reaction
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex






 

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