ENSMUSG00000039703


Mus musculus

Features
Gene ID: ENSMUSG00000039703
  
Biological name :Nploc4
  
Synonyms : Nploc4 / Nuclear protein localization / P60670
  
Possible biological names infered from orthology : NPL4 homolog, ubiquitin recognition factor / Q8TAT6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120380370
Gene end: 120437708
  
Corresponding Affymetrix probe sets: 10393774 (MoGene1.0st)   1454804_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035851
Ensembl peptide - ENSMUSP00000099306
NCBI entrez gene - 217365     See in Manteia.
MGI - MGI:2679787
RefSeq - XM_006533134
RefSeq - NM_001195023
RefSeq - NM_199469
RefSeq Peptide - NP_955763
RefSeq Peptide - NP_001181952
swissprot - P60670
Ensembl - ENSMUSG00000039703
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nploc4ENSDARG00000100487Danio rerio
 NPLOC4ENSGALG00000004583Gallus gallus
 NPLOC4ENSG00000182446Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR007716  NPL4, zinc-binding putative
 IPR007717  Nuclear pore localisation protein NPL4, C-terminal
 IPR016563  Nuclear protein localization protein 4
 IPR024682  Nuclear pore localisation protein Npl4, ubiquitin-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0030970 retrograde protein transport, ER to cytosol ISS
 biological_processGO:0032480 negative regulation of type I interferon production ISS
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex ISS
 cellular_componentGO:0036501 UFD1-NPL4 complex ISO
 cellular_componentGO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000023953 Polh / Q9JJN0 / DNA polymerase eta / Q9Y253*  / reaction / complex
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex
 ENSMUSG00000031986 Sprtn / G3X912 / SprT-like domain-containing protein Spartan / Q9H040* / SprT-like N-terminal domain*  / complex / reaction






 

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