ENSG00000182446


Homo sapiens

Features
Gene ID: ENSG00000182446
  
Biological name :NPLOC4
  
Synonyms : NPL4 homolog, ubiquitin recognition factor / NPLOC4 / Q8TAT6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 81556887
Gene end: 81648465
  
Corresponding Affymetrix probe sets: 217796_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465247
Ensembl peptide - ENSP00000461543
Ensembl peptide - ENSP00000467400
Ensembl peptide - ENSP00000486640
Ensembl peptide - ENSP00000331487
Ensembl peptide - ENSP00000363879
Ensembl peptide - ENSP00000458384
Ensembl peptide - ENSP00000459457
Ensembl peptide - ENSP00000459462
Ensembl peptide - ENSP00000460465
Ensembl peptide - ENSP00000461478
NCBI entrez gene - 55666     See in Manteia.
OMIM - 606590
RefSeq - XM_017024830
RefSeq - NM_017921
RefSeq - XM_011524979
RefSeq - XM_011524980
RefSeq - XM_011524981
RefSeq - XM_011524982
RefSeq Peptide - NP_060391
swissprot - I3L4U9
swissprot - K7EJN1
swissprot - A0A024R8R4
swissprot - Q8TAT6
swissprot - A0A0D9SFI9
swissprot - I3L0W3
swissprot - I3L281
swissprot - I3L283
swissprot - I3L4S2
swissprot - I3L3I1
Ensembl - ENSG00000182446
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nploc4ENSDARG00000100487Danio rerio
 NPLOC4ENSGALG00000004583Gallus gallus
 Nploc4ENSMUSG00000039703Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR007716  NPL4, zinc-binding putative
 IPR007717  Nuclear pore localisation protein NPL4, C-terminal
 IPR016563  Nuclear protein localization protein 4
 IPR024682  Nuclear pore localisation protein Npl4, ubiquitin-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IMP
 biological_processGO:0032480 negative regulation of type I interferon production IMP
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0070987 error-free translesion synthesis TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IDA
 cellular_componentGO:0036501 UFD1-NPL4 complex IPI
 cellular_componentGO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion Synthesis by POLH


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000170734 POLH / Q9Y253 / DNA polymerase eta  / reaction / complex
 ENSG00000010072 SPRTN / Q9H040 / SprT-like N-terminal domain  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000165280 VCP / P55072 / valosin containing protein  / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000070010 UFD1 / Q92890 / ubiquitin recognition factor in ER associated degradation 1  / complex






 

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