ENSMUSG00000056900


Mus musculus

Features
Gene ID: ENSMUSG00000056900
  
Biological name :Usp13
  
Synonyms : Q5BKP2 / ubiquitin specific peptidase 13 (isopeptidase T-3) / Usp13
  
Possible biological names infered from orthology : Q92995 / ubiquitin specific peptidase 13
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 32817546
Gene end: 32938071
  
Corresponding Affymetrix probe sets: 10491414 (MoGene1.0st)   1452442_at (Mouse Genome 430 2.0 Array)   1455473_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072155
Ensembl peptide - ENSMUSP00000103863
Ensembl peptide - ENSMUSP00000117605
Ensembl peptide - ENSMUSP00000133823
NCBI entrez gene - 72607     See in Manteia.
MGI - MGI:1919857
RefSeq - XM_006535553
RefSeq - XM_006535554
RefSeq - XM_006535555
RefSeq - XM_017319743
RefSeq - NM_001013024
RefSeq Peptide - NP_001013042
swissprot - Q5BKP2
swissprot - J3QSN2
swissprot - F6ZE47
swissprot - G3UXT9
Ensembl - ENSMUSG00000056900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp13ENSDARG00000079198Danio rerio
 USP13ENSGALG00000008909Gallus gallus
 USP13ENSG00000058056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp5 / P56399 / ubiquitin specific peptidase 5 (isopeptidase T) / P45974* / ubiquitin specific peptidase 5*ENSMUSG0000003842959


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR009060  UBA-like superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015940  Ubiquitin-associated domain
 IPR016652  Ubiquitinyl hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0035523 protein K29-linked deubiquitination ISO
 biological_processGO:0044313 protein K6-linked deubiquitination IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:1904294 positive regulation of ERAD pathway IEA
 biological_processGO:1904378 maintenance of unfolded protein involved in ERAD pathway IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0070628 proteasome binding IEA
 molecular_functionGO:1904288 BAT3 complex binding IEA
 molecular_functionGO:1904454 ubiquitin-specific protease activity involved in positive regulation of ERAD pathway IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / complex
 ENSMUSG00000036432 Siah2 / Q06986 / siah E3 ubiquitin protein ligase 2 / O43255*  / complex / reaction
 ENSMUSG00000005262 Ufd1 / P70362 / ubiquitin recognition factor in ER-associated degradation 1 / Q92890*  / complex / reaction
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / reaction / complex
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / reaction
 ENSMUSG00000031826 Usp10 / P52479 / ubiquitin specific peptidase 10 / Q14694*  / complex






 

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