ENSG00000058056


Homo sapiens

Features
Gene ID: ENSG00000058056
  
Biological name :USP13
  
Synonyms : Q92995 / ubiquitin specific peptidase 13 / USP13
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.33
Gene start: 179652755
Gene end: 179789401
  
Corresponding Affymetrix probe sets: 205356_at (Human Genome U133 Plus 2.0 Array)   226902_at (Human Genome U133 Plus 2.0 Array)   227788_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420057
Ensembl peptide - ENSP00000263966
Ensembl peptide - ENSP00000417146
Ensembl peptide - ENSP00000418651
NCBI entrez gene - 8975     See in Manteia.
OMIM - 603591
RefSeq - XM_017007427
RefSeq - NM_003940
RefSeq - XM_011513269
RefSeq - XM_017007425
RefSeq - XM_017007426
RefSeq Peptide - NP_003931
swissprot - Q92995
swissprot - H7C502
swissprot - H7C5J3
swissprot - A0A0A6YZ17
Ensembl - ENSG00000058056
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp13ENSDARG00000079198Danio rerio
 USP13ENSGALG00000008909Gallus gallus
 Usp13ENSMUSG00000056900Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP5 / P45974 / ubiquitin specific peptidase 5ENSG0000011166759


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR009060  UBA-like superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015940  Ubiquitin-associated domain
 IPR016652  Ubiquitinyl hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010506 regulation of autophagy IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0030318 melanocyte differentiation TAS
 biological_processGO:0035523 protein K29-linked deubiquitination IDA
 biological_processGO:0044313 protein K6-linked deubiquitination IDA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0070536 protein K63-linked deubiquitination IDA
 biological_processGO:1904294 positive regulation of ERAD pathway IMP
 biological_processGO:1904378 maintenance of unfolded protein involved in ERAD pathway IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0070628 proteasome binding IDA
 molecular_functionGO:1904288 BAT3 complex binding IDA
 molecular_functionGO:1904454 ubiquitin-specific protease activity involved in positive regulation of ERAD pathway IMP


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103194 USP10 / Q14694 / ubiquitin specific peptidase 10  / complex
 ENSG00000070010 UFD1 / Q92890 / ubiquitin recognition factor in ER associated degradation 1  / reaction / complex
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / reaction
 ENSG00000181788 SIAH2 / O43255 / siah E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / complex






 

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