ENSG00000181788


Homo sapiens

Features
Gene ID: ENSG00000181788
  
Biological name :SIAH2
  
Synonyms : O43255 / SIAH2 / siah E3 ubiquitin protein ligase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.1
Gene start: 150741127
Gene end: 150763477
  
Corresponding Affymetrix probe sets: 209339_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000322457
Ensembl peptide - ENSP00000417619
NCBI entrez gene - 6478     See in Manteia.
OMIM - 602213
RefSeq - NM_005067
RefSeq Peptide - NP_005058
swissprot - C9J9D7
swissprot - O43255
Ensembl - ENSG00000181788
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 siah2lENSDARG00000044381Danio rerio
 SIAH2ENSGALG00000010395Gallus gallus
 Siah2ENSMUSG00000036432Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIAH1 / Q8IUQ4 / siah E3 ubiquitin protein ligase 1ENSG0000019647069
SIAH3 / Q8IW03 / siah E3 ubiquitin protein ligase family member 3ENSG0000021547532


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004162  E3 ubiquitin-protein ligase SIN-like
 IPR008974  TRAF-like
 IPR013010  Zinc finger, SIAH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018121  Seven-in-absentia protein, TRAF-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0044257 cellular protein catabolic process IGI
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000058056 USP13 / Q92995 / ubiquitin specific peptidase 13  / complex / reaction
 ENSG00000064692 Q9Y6H5 / SNCAIP / synuclein alpha interacting protein  / reaction / complex
 ENSG00000145335 SNCA / P37840 / synuclein alpha  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction






 

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