ENSMUSG00000036432


Mus musculus

Features
Gene ID: ENSMUSG00000036432
  
Biological name :Siah2
  
Synonyms : Q06986 / Siah2 / siah E3 ubiquitin protein ligase 2
  
Possible biological names infered from orthology : O43255
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: D
Gene start: 58674938
Gene end: 58692400
  
Corresponding Affymetrix probe sets: 10498332 (MoGene1.0st)   1448170_at (Mouse Genome 430 2.0 Array)   1448171_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067496
NCBI entrez gene - 20439     See in Manteia.
MGI - MGI:108062
RefSeq - NM_009174
RefSeq Peptide - NP_033200
swissprot - Q06986
swissprot - Q3UEV2
Ensembl - ENSMUSG00000036432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 siah2lENSDARG00000044381Danio rerio
 SIAH2ENSGALG00000010395Gallus gallus
 SIAH2ENSG00000181788Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Siah1a / P61092 / E3 ubiquitin-protein ligase SIAH1A / SIAH1* / Q8IUQ4* / siah E3 ubiquitin protein ligase 1*ENSMUSG0000003684068
Siah1b / siah E3 ubiquitin protein ligase 1B / SIAH1* / Q8IUQ4* / siah E3 ubiquitin protein ligase 1*ENSMUSG0000004074967
Siah3 / siah E3 ubiquitin protein ligase family member 3 / Q8IW03*ENSMUSG0000009172232


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004162  E3 ubiquitin-protein ligase SIN-like
 IPR008974  TRAF-like
 IPR013010  Zinc finger, SIAH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018121  Seven-in-absentia protein, TRAF-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Ub-specific processing proteases
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000056900 Usp13 / Q5BKP2 / ubiquitin specific peptidase 13 (isopeptidase T-3) / Q92995* / ubiquitin specific peptidase 13*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex






 

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