ENSG00000196470


Homo sapiens

Features
Gene ID: ENSG00000196470
  
Biological name :SIAH1
  
Synonyms : Q8IUQ4 / SIAH1 / siah E3 ubiquitin protein ligase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q12.1
Gene start: 48356364
Gene end: 48448402
  
Corresponding Affymetrix probe sets: 202980_s_at (Human Genome U133 Plus 2.0 Array)   202981_x_at (Human Genome U133 Plus 2.0 Array)   232365_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369343
Ensembl peptide - ENSP00000456421
Ensembl peptide - ENSP00000457415
Ensembl peptide - ENSP00000349156
Ensembl peptide - ENSP00000378214
NCBI entrez gene - 6477     See in Manteia.
OMIM - 602212
RefSeq - XM_011523279
RefSeq - NM_001006610
RefSeq - NM_003031
RefSeq - XM_006721246
RefSeq Peptide - NP_003022
RefSeq Peptide - NP_001006611
swissprot - Q8IUQ4
swissprot - H3BU09
Ensembl - ENSG00000196470
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 siah1ENSDARG00000030871Danio rerio
 SIAH1ENSGALG00000003916Gallus gallus
 P61092ENSMUSG00000036840Mus musculus
 Siah1bENSMUSG00000040749Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIAH2 / O43255 / siah E3 ubiquitin protein ligase 2ENSG0000018178871
SIAH3 / Q8IW03 / siah E3 ubiquitin protein ligase family member 3ENSG0000021547533


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004162  E3 ubiquitin-protein ligase SIN-like
 IPR008974  TRAF-like
 IPR013010  Zinc finger, SIAH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018121  Seven-in-absentia protein, TRAF-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030163 protein catabolic process IDA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0051402 neuron apoptotic process ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000064692 Q9Y6H5 / SNCAIP / synuclein alpha interacting protein  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000145335 SNCA / P37840 / synuclein alpha  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr