ENSG00000111667


Homo sapiens

Features
Gene ID: ENSG00000111667
  
Biological name :USP5
  
Synonyms : P45974 / ubiquitin specific peptidase 5 / USP5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 6852128
Gene end: 6866632
  
Corresponding Affymetrix probe sets: 206031_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444668
Ensembl peptide - ENSP00000229268
Ensembl peptide - ENSP00000373883
NCBI entrez gene - 8078     See in Manteia.
OMIM - 601447
RefSeq - NM_003481
RefSeq - NM_001098536
RefSeq Peptide - NP_001092006
RefSeq Peptide - NP_003472
swissprot - P45974
swissprot - A0A140VJZ1
swissprot - F5H571
Ensembl - ENSG00000111667
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp5ENSDARG00000014517Danio rerio
 USP5ENSGALG00000014525Gallus gallus
 Usp5ENSMUSG00000038429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP13 / Q92995 / ubiquitin specific peptidase 13ENSG0000005805659


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR009060  UBA-like superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015940  Ubiquitin-associated domain
 IPR016652  Ubiquitinyl hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0071108 protein K48-linked deubiquitination IMP
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170315 UBB / P0CG47 / ubiquitin B  / reaction
 ENSG00000150991 UBC / P0CG48 / ubiquitin C  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr