ENSDARG00000014517


Danio rerio

Features
Gene ID: ENSDARG00000014517
  
Biological name :usp5
  
Synonyms : ubiquitin specific peptidase 5 (isopeptidase T) / usp5
  
Possible biological names infered from orthology : P45974 / P56399 / ubiquitin specific peptidase 5
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 11965371
Gene end: 11986321
  
Corresponding Affymetrix probe sets: Dr.20192.1.A1_at (Zebrafish Array)   NM_214755_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000036699
Ensembl peptide - ENSDARP00000124239
NCBI entrez gene - 406618     See in Manteia.
RefSeq - NM_214755
RefSeq - XM_005173477
RefSeq Peptide - NP_999920
swissprot - Q1MT86
swissprot - F8W4C4
ZFIN ID - ZDB-GENE-040426-2584
Ensembl - ENSDARG00000014517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP5ENSGALG00000014525Gallus gallus
 USP5ENSG00000111667Homo sapiens
 Usp5ENSMUSG00000038429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp13 / F1QFS9 / ubiquitin specific peptidase 13 / Q92995* / Q5BKP2* / ubiquitin specific peptidase 13 (isopeptidase T-3)*ENSDARG0000007919854


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR009060  UBA-like superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015940  Ubiquitin-associated domain
 IPR016652  Ubiquitinyl hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:1904888 cranial skeletal system development IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head malformed , abnormal
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 ZFA:0001115 trunk trunk immature , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage shape , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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 ZFA:0001604 caudal fin upper lobe caudal fin upper lobe fused with caudal fin lower lobe , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000102632 ubc / ubiquitin C / P0CG48* / P0CG50*  / reaction






 

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