MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0000222 | decreased neutrophil count | "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0000223 | decreased monocyte count | "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0008044 | increased NK cell number | "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0008211 | decreased mature B cell number | "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0008347 | decreased gamma-delta T cell number | "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0010169 | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0010845 | decreased effector memory CD4-positive, alpha-beta T cell number | "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0011095 | complete embryonic lethality between implantation and placentation | "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith] |
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve
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MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd
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MP:0012764 | increased alpha-beta T cell number | "greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0013023 | decreased Ly6C high monocyte number | "decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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MP:0013026 | decreased Ly6C low monocyte number | "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak] |
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+ Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi
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